Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control
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Summary
It is demonstrated how chromosome instability can arise as a by-product of defects in cell cycle control that compromise the accuracy of mitosis, and a new model is suggested to explain the frequent appearance of aneuploidy in human cancer.
- Type
- article
- Published
- 2004-08-12
- Cited by
- 578
- References
- 76
- Access
- Open access
- OpenAlex
- https://openalex.org/W1984328656
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4431976
Keywords
Mad2, Mitosis, Biology, Chromosome instability, Aneuploidy
References
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- Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling.
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- Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors
- Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated
- Deregulated cyclin E induces chromosome instability
- Chromosome segregation and cancer: cutting through the mystery
- Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells.
- Selective induction of LTP and LTD by postsynaptic [Ca2+]i elevation.
- MAP kinase phosphatases
- Characterization of MAD2B and other mitotic spindle checkpoint genes.
- Special newborn care and cot occupancy.
- Modal gating of NMDA receptors and the shape of their synaptic response
- Mad2 transiently associates with an APC/p55Cdc complex during mitosis.
- Reprogramming transcription during the differentiation of precursor CD4+ T cells into effector Th1 and Th2 cells.
- MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases
- Magnesium gates glutamate-activated channels in mouse central neurones
Cited by
- Chromosome instability and kinetochore dysfunction.
- Integrated genomic profiling of chronic lymphocytic leukemia identifies subtypes of deletion 13q14.
- The spindle checkpoint and chromosomal stability.
- Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis
- Mitotic chromosomal instability and cancer: mouse modelling of the human disease
- Exposure of neuroblastoma cell lines to imatinib results in the upregulation of the CDK inhibitor p27(KIP1) as a consequence of c-Abl inhibition.
- Genetic and Epigenetic Discoveries in Human Retinoblastoma
- Prognostic relevance of genetic alterations in diffuse lower-grade gliomas
- Genetic alterations in main candidate genes during melanoma progression
- Knudson to embryo selection: A story of the genetics of retinoblastoma
- Mad revival of cancer
- Targetable genetic features of primary testicular and primary central nervous system lymphomas.
- Investigation into how mitotic spindle checkpoint function is compromised by SV40 large T antigen.
- Deregulation of the centrosome cycle and the origin of chromosomal instability in cancer.
- Mutation of the retinoblastoma tumor suppressor gene sensitizes cancers to mitotic inhibitor induced cell death.
- Viral carcinogenesis and genomic instability.
- Targeting Rb inactivation in cancers by synthetic lethality
- Characterizing the contribution of the LXCXE binding cleft to pRB-mediated genome stability and tumor suppression
- Tumor Suppressor Loss and Mitotic Checkpoint Overactivation as a Crossroads to Cancer
- Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during Transformation
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