Genomic diversity of Philadelphia-positive chronic myelogenous leukemia.
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Summary
The prognostic and hematologic features of patients with variant translocations are not significantly different from those of CML cases with the typical 9q;22q translocation, but some of these complex translocations, where the breakpoints are correlated with oncogenetic sites, are further discussed in molecular terms.
- Type
- review
- Published
- 1987-01-01
- Cited by
- 19
- References
- 124
- OpenAlex
- https://openalex.org/W1983450285
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24374787
Keywords
Chromosomal translocation, Breakpoint, Chronic myelogenous leukemia, Incidence (geometry), Philadelphia chromosome
References
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- Secondary chromosome changes in chronic myeloid leukemia: Relation to treatment
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- Unusual Ph translocations in CML: four new cases.
- Chronic granulocytic leukemia following successful renal transplantation
- Is the chromosomal region 9q34 always involved in variants of the Ph1 translocation?
- A new complex translocation in chronic myelogenous leukemia with monoblastic crisis.
- Letter: PH1 translocation involving chromosomes 21 and 22.
Cited by
- Two new chromosomal abnormalities in chronic myelogenous leukemia 46,XY,t(9;15;22)(q34;q22;q11) and 46,XY,t(6;9;12;22)(p21;q34;q24;q11).
- A new translocation involving chromosomes 8 and 9 in a Philadelphia-negative chronic myelogenous leukemia.
- Chromosome abnormalities in CML.
- Clonal expansion after bone marrow transplantation in a patient with chronic myelogenous leukemia
- Characterization of a complex translocation [t(4;9;22)(p16;q34;q11)] in chronic myelogenous leukemia by fluorescence in situ hybridization technique.
- Serendipity of Philadelphia chromosome.
- Disappearance of a highly unusual clone, 46,XY,del(7)(p12),t(9;22)(q34;q11) in chronic myeloid leukemia after treatment with recombinant interferon and cytosine arabinoside.
- Unusual clonal evolution during blast crisis of chronic myeloid leukaemia (CML)
- New translocations [t(6;15)(p25;q22) and t(6;19)(q16;q13.3)] with t(9;22)(q34;q11) in a Ph-positive chronic myelogenous leukemia.
- Cytogenetic and Molecular Genetic Evolution of Chronic Myeloid Leukemia
- Location of breakpoints within the major breakpoint cluster region (bcr) in 33 patients with bcr rearrangement‐positive chronic myeloid leukemia (CML) with complex or absent Philadelphia chromosomes
- On the topology of normal chromatids and on their translocations in myelogenous leukemia.
- Complex translocations, simple variant translocations and Ph-negative cases in chronic myelogenous leukaemia
- Direct visualization of the transposed ABL gene in a duplicated masked Ph chromosome
- [The molecular-cytogenetic characterization and tyrosine kinase inhibitors efficacy in newly diagnosed chronic phase CML patients with variant Philadelphia chromosomes].
- Cytogenetics of Chronic Myeloid Leukemia (CML)
- The role of the BCR/ABL oncogene in human leukemia
- Chromosomal basis of hematologic malignancies
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