Attenuation of Mouse Mesangial Cell Contractility by High Glucose and Mannitol: Involvement of Protein Kinase C and Focal Adhesion Kinase
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Summary
Results may provide a correlation between increased expression of several PKC isoforms and, in particular, increased phosphorylation levels of PKCα and δ and hypocontractility induced by high glucose and mannitol treatment.
- Type
- article
- Published
- 2004-02-19
- Cited by
- 23
- References
- 51
- OpenAlex
- https://openalex.org/W1982863083
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11636025
Keywords
Protein kinase C, Focal adhesion, Mesangial cell, Tyrosine phosphorylation, PTK2
References
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- Mechanism of Interaction of Protein Kinase C with Phorbol Esters
- Monitoring diabetic nephropathy: glomerular filtration rate and abnormal albuminuria in diabetic renal disease--reproducibility, progression, and efficacy of antihypertensive intervention.
- High glucose levels inhibit focal adhesion kinase-mediated wound healing of rat peritoneal mesothelial cells.
- Insulin-Like Growth Factor I
- Altered expression and subcellular localization of diacylglycerol-sensitive protein kinase C isoforms in diabetic rat glomerular cells.
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- Biochemical signals and biological responses elicited by the focal adhesion kinase.
- Protein kinase C-mediated tyrosine phosphorylation of paxillin and focal adhesion kinase requires cytoskeletal integrity and is uncoupled to mitogen-activated protein kinase activation in human hepatoma cells.
- Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins.
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- Control of Ser2448 Phosphorylation in the Mammalian Target of Rapamycin by Insulin and Skeletal Muscle Load*
- Early glomerular hyperfiltration and the development of late nephropathy in Type 1 (insulin-dependent) diabetes mellitus
- Diabetic nephropathy: prevention and treatment.
- A Role for Focal Adhesion Kinase in Phenylephrine-induced Hypertrophy of Rat Ventricular Cardiomyocytes*
- Signaling transduction pathway of angiotensin II in human mesangial cells: mediation of focal adhesion and GTPase activating proteins.
Cited by
- Characterization of the mechanisms of the increase in PPARδ expression induced by digoxin in the heart using the H9c2 cell line
- Cytokines in diabetic nephropathy.
- Attributes of antiangiogenic factor plasminogen kringle 5 in glomerulonephritis.
- The role of novel protein-protein interactions in the function and mechanism of the sarcomeric protein, myosin binding protein H (MyBPH)
- Revealing the underlying mechanism of diabetic nephropathy viewed by microarray analysis.
- Effects of fungal statins on high-glucose-induced mouse mesangial cell hypocontractility may involve filamentous actin, t-complex polypeptide 1 subunit beta, and glucose regulated protein 78.
- Hypo- and Hyperglycemia Impair Endothelial Cell Actin Alignment and Nitric Oxide Synthase Activation in Response to Shear Stress
- Inflammation and Oxidative Stress in Diabetic Nephropathy: New Insights on Its Inhibition as New Therapeutic Targets
- Effects of mannitol alone and mannitol plus furosemide on renal oxygen consumption, blood flow and glomerular filtration after cardiac surgery
- Emodin ameliorates high-glucose induced mesangial p38 over-activation and hypocontractility via activation of PPARγ
- Detailed glomerular ultrastructure in Japanese type 2 diabetic patients by the quick-freezing and deep-etching method.
- Hyperglycemia Reduces Survival and Impairs Function of Circulating Blood-Derived Progenitor Cells
- Involvement of F-Actin in Chaperonin-Containing t-Complex 1 Beta Regulating Mouse Mesangial Cell Functions in a Glucose-Induction Cell Model
- Role of T Cells in Type 2 Diabetic Nephropathy
- Percentage of Circulating CD8+ T Lymphocytes is Associated with Albuminuria in Type 2 Diabetes Mellitus
- From obesity through immunity to type 2 diabetes mellitus
- High glucose downregulates myocardin expression in rat glomerular mesangial cells via the ERK signaling pathway
- Mitochondria-targeted drugs for diabetic kidney disease
- Cellular mechanism of action of forsythiaside for the treatment of diabetic kidney disease
- Association between dietary inflammatory index (DII) and diabetic nephropathy in type 2 diabetic patients: a case-control study
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