Cellular radiosensitivity, radioresistant DNA synthesis, and defect in radioinduction of p53 in fibroblasts from atherosclerosis patients.
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Summary
Cellular/molecular defects leading to increased radiosensitivity, reduced induction of p53/p21, and cell cycle deregulation found to be associated with cancer-prone disorders such as AT may constitute important risk factors for atherosclerosis as well.
- Type
- article
- Published
- 1997-05-01
- Cited by
- 13
- References
- 40
- OpenAlex
- https://openalex.org/W1982247051
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44341281
Keywords
Radioresistance, Radiosensitivity, DNA synthesis, DNA, Cancer research
References
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- Participation of p53 protein in the cellular response to DNA damage.
- Relationships between G1 arrest and stability of the p53 and p21Cip1/Waf1 proteins following gamma-irradiation of human lymphoma cells.
- International Commission for Protection Against Environmental Mutagens and Carcinogens. ICPEMC Working Paper 7/1/2. Shared risk factors for cancer and atherosclerosis--a review of the epidemiological evidence.
- Benzo(a)pyrene enhances atherosclerosis in White Carneau and Show Racer pigeons.
- Proof without prejudice: use of the Kolmogorov-Smirnov test for the analysis of histograms from flow systems and other sources.
- A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.
- Transforming gene in human atherosclerotic plaque DNA.
- The v-abl, c-fms, or v-myc oncogene induces gamma radiation resistance of hematopoietic progenitor cell line 32d cl 3 at clinical low dose rate.
- Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction.
- Checkpoints: controls that ensure the order of cell cycle events.
- Cell cycle alterations, apoptosis, and response to low-dose-rate radioimmunotherapy in lymphoma cells.
- WAF1, a potential mediator of p53 tumor suppression.
- Intracranial atherosclerosis following radiotherapy
Cited by
- Biologie radiogener arteriosklerotischer Läsionen
- DNA damage repair and cardiovascular diseases.
- Effect of Ionizing Radiation on Rat Vascular Smooth Muscle Cell
- Induction of p53 and p21 proteins by gamma radiation in skin fibroblasts derived from breast cancer patients.
- Nijmegen breakage syndrome 1 protein hyperacetylation as a molecular mechanism underlying metabolic syndrome
- ATM protects against oxidative stress induced by oxidized low-density lipoprotein
- Genetic influence on cigarette-induced cardiovascular disease.
- Smoking-gene Interaction and Disease Development: Relevance to Pancreatic Cancer and Atherosclerosis
- Mortality Rates among Carriers of Ataxia-Telangiectasia Mutant Alleles
- Evidence that Individual Variations in TP53 and CDKN1A Protein Responsiveness are Related to Inherent Radiation Sensitivity
- Human primary fibroblasts in vitro express a purinergic P2X7 receptor coupled to ion fluxes, microvesicle formation and IL-6 release.
- Inhibition of DNA synthesis by ionizing radiation.
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