A Novel Protein Kinase-Like Domain in a Selenoprotein, Widespread in the Tree of Life
Explore this paper's citation graph
Summary
It is argued that despite the lack of conservation of the “classic” catalytic aspartate residue of the archetypical His-Arg-Asp motif, SELO kinases might have retained catalytic phosphotransferase activity, albeit with an atypical active site.
- Type
- article
- Published
- 2012-02-16
- Cited by
- 66
- References
- 160
- Access
- Open access
- OpenAlex
- https://openalex.org/W1981899788
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3935696
Keywords
Selenoprotein, Selenocysteine, Biochemistry, Oxidoreductase, Kinase
References
- Genetic analysis of the isc operon in Escherichia coli involved in the biogenesis of cellular iron-sulfur proteins.
- Secondary structure prediction with support vector machines
- Genome-Wide Transcriptional Analysis of the Cold Shock Response in Wild-Type and Cold-Sensitive, Quadruple-csp-Deletion Strains of Escherichia coli
- Protein structure prediction based on sequence similarity.
- Binding of nucleotides by proteins
- Fluorescent nucleotide analogs: synthesis and applications.
- MUSCLE: a multiple sequence alignment method with reduced time and space complexity
- IscR acts as an activator in response to oxidative stress for the suf operon encoding Fe‐S assembly proteins
- Quantitative analysis of protein phosphorylation on a system-wide scale by mass spectrometry-based proteomics.
- Identification of the btuCED polypeptides and evidence for their role in vitamin B12 transport in Escherichia coli
- Phosphotransferase and substrate binding mechanism of the cAMP‐dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5‐24).
- Exploration of Uncharted Regions of the Protein Universe
- Drug discovery and the human kinome: recent trends.
- SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis.
- Investigations of the MceIJ-catalyzed posttranslational modification of the microcin E492 C-terminus: linkage of ribosomal and nonribosomal peptides to form "trojan horse" antibiotics.
- Novel conserved hydrolase domain in the CLCA family of alleged calcium‐activated chloride channels
- Conserved herpesvirus protein kinases.
- The oligomeric conformation of peroxiredoxins links redox state to function
- Mitochondrial kinases in cell signaling: Facts and perspectives.
- Influence of SelS gene silence on beta-Mercaptoethanol-mediated endoplasmic reticulum stress and cell apoptosis in HepG2 cells.
Cited by
- Selenium biochemistry and its role for human health.
- Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases.
- PlantRNA, a database for tRNAs of photosynthetic eukaryotes
- Selenium prevents downregulation of antioxidant selenoprotein genes by methylmercury.
- Intersection of selenoproteins and kinase signalling.
- Knockdown of Selenocysteine-Specific Elongation Factor in Amblyomma maculatum Alters the Pathogen Burden of Rickettsia parkeri with Epigenetic Control by the Sin3 Histone Deacetylase Corepressor Complex
- Selenoproteins: molecular pathways and physiological roles.
- A Novel Predicted Calcium-Regulated Kinase Family Implicated in Neurological Disorders
- Characterization of Mammalian Selenoprotein O: A Redox-Active Mitochondrial Protein
- CLCAs - A Family of Metalloproteases of Intriguing Phylogenetic Distribution and with Cases of Substituted Catalytic Sites
- Characterization of a novel chicken muscle disorder through differential gene expression and pathway analysis using RNA-sequencing
- RNA-sequencing analysis of Wooden Breast disease: characterization of a novel muscle disease in chickens through differential gene expression and pathway analysis
- The effects of selenium on methylmercury toxicity in zebrafish
- Comparative Genomics of cpn60-Defined Enterococcus hirae Ecotypes and Relationship of Gene Content Differences to Competitive Fitness
- Selenoprotein O deficiencies suppress chondrogenic differentiation of ATDC5 cells
- Contribution of mammalian selenocysteine-containing proteins to carcinogenesis.
- Supranutritional dietary selenium induced hyperinsulinemia and dyslipidemia via affected expression of selenoprotein genes and insulin signal-related genes in broiler
- Biochemical characterization of the selenoproteome in Gallus gallus via bioinformatics analysis: structure-function relationships and interactions of binding molecules.
- The secret life of kinases: insights into non-catalytic signalling functions from pseudokinases.
- SELENOPROTEIN O is a chloroplast protein involved in ROS scavenging and its absence increases dehydration tolerance in Arabidopsis thaliana.
Related papers
- Why Multiples of 21? Why does Selenoprotein P Contain Multiple Selenocysteine Residues?
- Orphan selenoproteins.
- Responsiveness of selenoproteins to dietary selenium.
- Nutritional Biochemistry of Selenium
- Regulation of Selenocysteine Incorporation into the Selenium Transport Protein, Selenoprotein P*
- The algal selenoproteomes
- Expression of selenoproteins via genetic code expansion in mammalian cells