Cell surface engineering by a modified Staudinger reaction.
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Summary
A chemical transformation that permits the selective formation of covalent adducts among richly functionalized biopolymers within a cellular context is presented and should permit its execution within a cell's interior, offering new possibilities for probing intracellular interactions.
- Type
- article
- Published
- 2000-03-17
- Cited by
- 2,095
- References
- 12
- OpenAlex
- https://openalex.org/W1981659539
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19720277
Keywords
Bioorthogonal chemistry, Chemistry, Azide, Covalent bond, Context (archaeology)
References
- Exploiting differences in sialoside expression for selective targeting of MRI contrast reagents
- Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells.
- Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis.
- Recent Advances in the Staudinger Reaction
- Über neue organische Phosphorverbindungen III. Phosphinmethylenderivate und Phosphinimine
- Engineering Novel Cell Surface Receptors for Virus-mediated Gene Transfer*
- Metabolic Delivery of Ketone Groups to Sialic Acid Residues
- Inner space exploration: the chemical biologist's guide to the cell.
- Disaccharide uptake and priming in animal cells: inhibition of sialyl Lewis X by acetylated Gal beta 1-->4GlcNAc beta-O-naphthalenemethanol.
- Efficient introduction of alkene functionality into proteins in vivo
- The reaction between thiols and 8-azidoadenosine derivatives.
- Specific covalent labeling of recombinant protein molecules inside live cells.
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- Development of chemical tools for studying two unusual forms of protein O-glycosylation
- Cell wall engineering of living bacteria through biosynthesis.
- Chemical biology: Hitting the sweet spot
- Sequence specific recruitment of proteins to the inner membrane complex of the malaria parasite Plasmodium falciparum (Welch, 1897)
- Diels-Alder ligation of peptides and proteins.
- Protein chemical synthesis in drug discovery.
- Synthetic chemoselective rewiring of cell surfaces: generation of three-dimensional tissue structures.
- The controlled display of biomolecules on nanoparticles: a challenge suited to bioorthogonal chemistry.
- Orthogonality in discrete self-assembly--survey of current concepts.
- Protein engineering for directed immobilization.
- Rapid labeling of metabolically engineered cell-surface glycoconjugates with a carbamate-linked cyclopropene reporter.
- Improved cyclopropene reporters for probing protein glycosylation.
- Cell-free identification of novel N-myristoylated proteins from complementary DNA resources using bioorthogonal myristic acid analogues.
- Small gold nanoparticles for interfacial Staudinger-Bertozzi ligation.
- Bioorthogonal Labeling, Bioimaging, and Photocytotoxicity Studies of Phosphorescent Ruthenium(II) Polypyridine Dibenzocyclooctyne Complexes.
- Super-Resolution Imaging of Plasma Membrane Proteins with Click Chemistry
- Fine-Tuning Strain and Electronic Activation of Strain-Promoted 1,3-Dipolar Cycloadditions with Endocyclic Sulfamates in SNO-OCTs
- Cell membrane engineering with synthetic materials: Applications in cell spheroids, cellular glues and microtissue formation.
- Design, Synthesis, And Testing Of Multivalent Compounds Targeted To Melanocortin Receptors
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