Synergistic effect of gene‐electro transfer and adjuvant cytokines in increasing the potency of hepatitis C virus genetic vaccination
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Summary
Gene electro‐transfer increases DNA uptake and expression by muscle cells following intramuscular plasmid injection to increase the production of therapeutic proteins and to improve immunization efficiency following the injection of antigen‐encoding plasmids.
- Type
- article
- Published
- 2008-09-01
- Cited by
- 8
- References
- 32
- OpenAlex
- https://openalex.org/W1980998980
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32543143
Keywords
Plasmid, Adjuvant, Immunization, Virology, Potency
References
- Costimulation provided by DNA immunization enhances antitumor immunity.
- Modulating the immune response to genetic immunization
- Increased DNA Vaccine Delivery and Immunogenicity by Electroporation In Vivo
- Potent CD4+ T Cell Responses Elicited by a Bicistronic HIV-1 DNA Vaccine Expressing gp120 and GM-CSF1
- Delivery Systems for Gene-based Vaccines
- Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines.
- Modulation of Viral Immunoinflammatory Responses with Cytokine DNA Administered by Different Routes
- Human Immunodeficiency Virus Type 1-Specific Immunity after Genetic Immunization Is Enhanced by Modification of Gag and Pol Expression
- Role of interferons and other cytokines in the regulation of the immune response
- Can soluble antigens induce CD8+ cytotoxic T-cell responses? A paradox revisited.
- IFN-alpha promotes the rapid differentiation of monocytes from patients with chronic myeloid leukemia into activated dendritic cells tuned to undergo full maturation after LPS treatment.
- Dendritic Cells Infiltrating Tumors Cotransduced with Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf) and Cd40 Ligand Genes Take up and Present Endogenous Tumor-Associated Antigens, and Prime Naive Mice for a Cytotoxic T Lymphocyte Response
- MHC class I-restricted CTL responses to exogenous antigens.
- Particle-Mediated Gene Transfer of Granulocyte-Macrophage Colony-Stimulating Factor cDNA to Tumor Cells: Implications for a Clinically Relevant Tumor Vaccine
- Liver-Specific Alpha 2 Interferon Gene Expression Results in Protection from Induced Hepatitis
- Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines.
- Adjuvant formulations and delivery systems for DNA vaccines.
- In vivo cytokine gene transfer by gene gun reduces tumor growth in mice.
- Gene electro‐transfer improves transduction by modifying the fate of intramuscular DNA
- Venezuelan equine encephalitis virus vectors expressing HIV-1 proteins: vector design strategies for improved vaccine efficacy.
Cited by
- Advances in DNA immunization against hepatitis C virus infection: Opportunities and challenges
- ErbB2 Genetic Cancer Vaccine in Nonhuman Primates: Relevance of Single Nucleotide Polymorphisms
- Electroporation Delivery of DNA Vaccines: Prospects for Success
- Antiapoptotic Small Interfering RNA as Potent Adjuvant of DNA Vaccination in a Mouse Mammary Tumor Model
- Microsecond and nanosecond electric pulses in cancer treatments
- Immunopotentiating and Delivery Systems for HCV Vaccines
- DNA Vaccination by Electrogene Transfer
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