The multiple roles of glutathione in drug metabolism
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Summary
Glutathione conjugation can, in some cases, result in toxicity, and glutathione oxidation during hydro peroxide metabolism may precipitate the early loss of Ca 2+ homeostatis associated with hydroperoxide-induced cytotoxicity.
- Type
- article
- Published
- 1984-01-01
- Cited by
- 142
- References
- 10
- OpenAlex
- https://openalex.org/W1980997377
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:83841852
Keywords
Glutathione, Chemistry, Glutathione metabolism, Toxicity, Metabolism
References
- The activating role of glutathione in the mutagenicity of 1,2-dibromoethane.
- Enzymatic basis of detoxication
- Functions of Glutathione: Biochemical, Physiological, Toxicological, and Clinical Aspects
- Formaldehyde dehydrogenase from human liver. Purification, properties, and evidence for the formation of glutathione thiol esters by the enzyme.
- Metabolism of glutathione and a glutathione conjugate by isolated kidney cells.
- The glutathione status of cells.
- Cysteine conjugate beta-lyase in rat liver. A novel enzyme catalyzing formation of thiol-containing metabolites of drugs.
- Prostaglandin synthetase catalyzed activation of paracetamol.
- Competition between transport of glutathione disulfide (GSSG) and glutathione S‐conjugates from perfused rat liver into bile
- Alterations in thiol and calcium-ion homoeostasis during hydroperoxide and drug metabolism in hepatocytes.
- Drug Reactions and the Liver
Cited by
- Modulatory influence of camphor on the activities of hepatic carcinogen metabolizing enzymes and the levels of hepatic and extrahepatic reduced glutathione in mice.
- Mesangial cells but not hepatocytes are protected against NO/O(2)(-) cogeneration: mechanistic considerations.
- Cryopreservation of Hepatocytes.
- Glutathione, free radicals and chemotherapeutic agents. Mechanisms of free-radical induced toxicity and glutathione-dependent protection.
- Chemomodulatory action of Brassica compestris (var sarason) on hepatic carcinogen metabolizing enzymes, antioxidant profiles and lipid peroxidation.
- Expressions of mercury-selenium interaction in vitro.
- Glutathione conjugation in male reproductive system: studies on glutathione-S-transferase of bull and boar epididymis.
- The Development, Validation and Implementation of a Broad-Based ADME Genotyping Assay into Research and Clinical Trials
- Body Weight-Dependent Pharmacokinetics of Busulfan in Paediatric Haematopoietic Stem Cell Transplantation Patients
- Bases moleculares de la depleción de glutatión y de la necrosis celular en la pancreatitis aguda. Papel de las proteín quinasas activadas por mitógenos.
- INDUCTION OFγ-GLUTAMYLCYSTEINE SYNTHETASE BY PROSTAGLANDIN A 2 IN CULTURED MAMMALIAN CELLS
- Computational study on mechanisms of the anticancer drug: Cisplatin and novel polynuclear platinum(II) interaction with sulfur-donor biomolecules and DNA purine bases
- Mecanismo de producción de radicales libres en la diabetes: Importancia de la xantina oxidasa e implicación del factor nuclear-KB
- Exploring the Effect of Cytisus Scoparius on Markers of Oxidative Stress in Rats
- Stimulation of glutathione absorption in rat small intestine by α‐adrenergic agonists
- Effect of L-penicillamine hydantoin, an analogue of glutathione, on rat liver glutathione peroxidase, reductase and transferase reactions.
- Effect of Diet on Some Rat Liver Plasma Membrane and Intestinal Enzymes in Subacute Galactosamine Hepatitis
- Lack of effect of glutathione depletion on cytotoxicity, mutagenicity and DNA damage produced by doxorubicin in cultured cells.
- Glutathione Stability in Whole Blood: Effects of Various Deproteinizing Acids
- Dose-dependent effects of dichloropropanol on liver histology and lipid peroxidation in rats.
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