Expression of alternative isoforms of the neural cell adhesion molecule (NCAM) on normal brain and a variety of brain tumours
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Summary
The identification of another NCAM isoform of 95 kDa that is apparent on tissues following either N‐glycanase or neuraminidase treatment to remove carbohydrate and sialic acid residues from the molecule respectively is reported.
- Type
- article
- Published
- 1991-06-01
- Cited by
- 21
- References
- 13
- OpenAlex
- https://openalex.org/W1980581525
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9539083
Keywords
Neural cell adhesion molecule, Sialic acid, Biology, Gene isoform, Polysialic acid
References
- Differential exon usage involving an unusual splicing mechanism generates at least eight types of NCAM cDNA in mouse brain.
- Adult human brain expresses four different molecular forms of neural cell adhesion molecules.
- The use of monoclonal antibodies for the diagnosis of intracranial malignancies and the small round cell tumours of childhood
- Alternative splicing generates a secreted form of N-CAM in muscle and brain.
- Polypeptide variation in an N-CAM extracellular immunoglobulin-like fold is developmentally regulated through alternative splicing.
- Neural cell adhesion molecule (NCAM) is the antigen recognized by monoclonal antibodies of similar specificity in small‐cell lung carcinoma and neuroblastoma
- Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing.
- Biosynthesis, membrane association, and release of N-CAM-120, a phosphatidylinositol-linked form of the neural cell adhesion molecule
- Human muscle neural cell adhesion molecule (N-CAM): identification of a muscle-specific sequence in the extracellular domain.
- Alternatively spliced mRNAs code for different polypeptide chains of the chicken neural cell adhesion molecule (N-CAM)
- Monoclonal antibody UJ13A recognizes the neural cell adhesion molecule (NCAM)
- Skeletal muscle neural cell adhesion molecule (N-CAM): changes in protein and mRNA species during myogenesis of muscle cell lines
- Morphoregulatory molecules.
Cited by
- Monoclonal Antibody Therapy of Human Gliomas: Current Status and Future Approaches
- Neuroblastoma in the very young child: biological considerations.
- Cellular and molecular pathology of medulloblastoma
- Expression of the neural cell adhesion molecule (NCAM) on the haemopoietic cell line Nalm-16.
- A discordance between the human muscle NCAM sequence and those seen in other NCAM cDNA clones.
- Primitive neuroectodermal tumors of the central nervous system in childhood: tumor biological aspects.
- Complementary DNA sequence encoding the major neural cell adhesion molecule isoform in a human small cell lung cancer cell line.
- Developmental Profile of Neural Cell Adhesion Molecule Glycoforms with a Varying Degree of Polymerization of Polysialic Acid Chains*
- Regional and Duration of Illness Differences in the Alteration of NCAM-180 mRNA Expression within the Cortex of Subjects with Schizophrenia
- Alteration of serum and tumoral neural cell adhesion molecule (NCAM) isoforms in patients with brain tumors
- Vase mini‐exon usage by ncam is not restricted to tumours of neuroectodermal origin
- Expression of the neural cell adhesion molecule in astrocytic tumors
- Immunohistochemical analysis for histopathological subtypes in pediatric medulloblastomas
- Tissue-specific expression of neural cell adhesion molecule (NCAM) may allow differential diagnosis of neuroblastoma from embryonal rhabdomyosarcoma.
- Characterization of Neural Cell Lines Derived from SV40 Large T‐Induced Primitive Neuroectodermal Tumors
- Expression of neural cell adhesion molecule (NCAM) isoforms in neuroblastoma.
- Neuroectodermal tumors of the peripheral and the central nervous system share neuroendocrine N-CAM-related antigens with small cell lung carcinomas
- Differential gene expression of the neural cell adhesion molecule (N-CAM) in a panel of multiple myeloma cell lines
- Splicing of the vase exon of neural cell adhesion molecule (NCAM) in human small‐cell lung carcinoma (SCLC)
- Localization and Tumor Growth Inhibition of I-131-Labeled Monoclonal Antibody ERIC1 in a Subcutaneous Xenograft Model of Small Cell Lung Cancer in SCID Mice
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