The acute effects of NMDA antagonism: from the rodent to the human brain.
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Summary
Evidence suggests that ketamine's effects are not restricted to pyramidal cells, but extend to GABAergic interneurons and the glia and other neurotransmitter systems are discussed, and increased extracellular glutamate levels following NMDA antagonist administration stand out as a well replicated finding.
- Type
- review
- Published
- 2009-05-01
- Cited by
- 182
- References
- 87
- OpenAlex
- https://openalex.org/W1980573935
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21963290
Keywords
NMDA receptor, Neuroscience, Ketamine, Glutamatergic, Glutamate receptor
References
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- A Specific Role for NR2A-Containing NMDA Receptors in the Maintenance of Parvalbumin and GAD67 Immunoreactivity in Cultured Interneurons
- Selectively increasing inducible heat shock protein 70 via TAT‐protein transduction protects neurons from nitrosative stress and excitotoxicity
- Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactions.
- Exchange of cystine and glutamate across plasma membrane of human fibroblasts.
- Excitatory amino acid-induced release of 3H-GABA from cultured mouse cerebral cortex interneurons
- N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells
- Mechanisms of excitotoxicity in neurologic diseases
- Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex
- Astrocytic contributions to bioenergetics of cerebral ischemia
- Acute phencyclidine neurotoxicity in rat forebrain: induction of haem oxygenase‐1 and attenuation by the antioxidant dimethylthiourea
- The Neurochemical Circuitry of Schizophrenia
- c‐fos expression and (14C) 2‐deoxyglucose uptake in the caudal cerebellum of the rat during motor/sensory cortex stimulation
- Sequential Regional Cerebral Blood Flow Brain Scans Using PET with H215O Demonstrate Ketamine Actions in CNS Dynamically
- Cell culture studies of the role of elevated extracellular glutamate and K+ in neuronal cell death during and after anoxia/ischemia.
- Repeated application of ketamine to rats induces changes in the hippocampal expression of parvalbumin, neuronal nitric oxide synthase and cFOS similar to those found in human schizophrenia.
- Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse
- Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration
Cited by
- Update on anti-N-methyl-D-aspartate receptor encephalitis in children and adolescents
- Impaired Cognitive Function and Altered Hippocampal Synapse Morphology in Mice Lacking Lrrtm1, a Gene Associated with Schizophrenia
- Effects of Anti-NMDA Antibodies on Functional Recovery and Synaptic Rearrangement Following Hemicerebellectomy
- Investigating the Primate Prefrontal Cortex Correlates of Cognitive Deficits In the Ketamine Model of Schizophrenia
- Novel routes to either racemic or enantiopure α-amino-(4-hydroxy-pyrrolidin-3-yl)acetic acid derivatives and biological evaluation of a new promising pharmacological scaffold.
- NMDA receptor antagonism by phencyclidine reduces NWASP and WAVE1 protein expression and reduces levels of myelination markers in the prefrontal cortex of rats
- Sedation for Critically Ill or Injured Adults in the Intensive Care Unit
- TiO2 nanoparticle‐induced neurotoxicity may be involved in dysfunction of glutamate metabolism and its receptor expression in mice
- Antidepressant mechanism of ketamine: perspective from preclinical studies
- Restructuring consciousness –the psychedelic state in light of integrated information theory
- A Mechanistic Investigation of Anesthesia-Induced Spatial Learning Deficits in Aged Rats
- Mice Lacking the Serotonin Htr2B Receptor Gene Present an Antipsychotic-Sensitive Schizophrenic-Like Phenotype
- FUNCTIONAL PLASTICITY OF HIPPOCAMPAL GLUTAMATERGIC SYNAPSES IN DEVELOPMENT AND DISEASE
- The prefrontal cortex and information processing : nitric oxide signaling studied in an animal model of schizophrenia
- Altered neuronal excitability underlies impaired hippocampal function in an animal model of psychosis
- Prolonged reversal of the phencyclidine-induced impairment in novel object recognition by a serotonin (5-HT)1A-dependent mechanism.
- Alterations of p75 neurotrophin receptor and Myelin transcription factor 1 in the hippocampus of perinatal phencyclidine treated rats.
- The adenosine neuromodulation system in schizophrenia.
- Adenosine Neuromodulation and Traumatic Brain Injury
- The [18F]FDG μPET Readout of a Brain Activation Model to Evaluate the Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator JNJ-42153605
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