Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin.
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Summary
Enzymatic targets for inhibitor design and therapeutic intervention are suggested by the similar ferric-ion ligation strategies used in the siderophores from Mycobacteria, Yersinia and E. coli pathogens.
- Type
- article
- Published
- 1998-11-01
- Cited by
- 421
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W1980530950
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25032571
Keywords
Nonribosomal peptide, Siderophore, Biology, Polyketide synthase, Enterobactin
References
- Analysis of the Exochelin Locus inMycobacterium smegmatis: Biosynthesis Genes Have Homology with Genes of the Peptide Synthetase Family
- Acyl carrier protein. X. Acyl carrier protein synthetase.
- Vibriobactin, a siderophore from Vibrio cholerae.
- Mycobactins: iron-chelating growth factors from mycobacteria.
- Isolation, purification and structure of exochelin MS, the extracellular siderophore from Mycobacterium smegmatis.
- Isolation, identification, and structural analysis of the mycobactins of Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium scrofulaceum, and Mycobacterium paratuberculosis
- Characterization of exochelins of Mycobacterium avium: evidence for saturated and unsaturated and for acid and ester forms
- Subcloning, expression, and purification of the enterobactin biosynthetic enzyme 2,3-dihydroxybenzoate-AMP ligase: demonstration of enzyme-bound (2,3-dihydroxybenzoyl)adenylate product.
- Exochelin genes in Mycobacterium smegmatis: identification of an ABC transporter and two non‐ribosomal peptide synthetase genes
- Structure elucidation of yersiniabactin, a siderophore from highly virulent Yersinia strains
- Modular organization of genes required for complex polyketide biosynthesis.
- Post-translational modification of polyketide and nonribosomal peptide synthases.
- Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases.
- The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716: molecular characterization of three multi-modular peptide synthetases.
- Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis.
- Enterobactin biosynthesis in Escherichia coli: isochorismate lyase (EntB) is a bifunctional enzyme that is phosphopantetheinylated by EntD and then acylated by EntE using ATP and 2,3-dihydroxybenzoate.
- Identification of genes involved in the sequestration of iron in mycobacteria: the ferric exochelin biosynthetic and uptake pathways
- Structure of anguibactin, a unique plasmid-related bacterial siderophore from the fish pathogen Vibrio anguillarum
- Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX.
- A new enzyme superfamily - the phosphopantetheinyl transferases.
Cited by
- Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis.
- Activity-Based Protein Profiling of Non-ribosomal Peptide Synthetases.
- Investigation of Proteins Involved in the Biosynthesis and Utilization of 2,3-Dihydroxybenzoic Acid, an Intermediate of E. coli Enterobactin Biosynthesis
- Structures and functions of microbial lipid antigens presented by CD1.
- Genómica evolutiva de la regulación transcripcional en las principales familias multigénicas del sistema quimiosensorial de Drosophila
- Characterization of Gene Expression During Biofilm Development in Mycobacterium smegmatis, and Genetic Analysis of a Surface Translocation-Defective Transposon Mutant
- Iron as a candidate in virulence and pathogenesis in mycobacteria and other microorganisms
- Protein-Protein Interactions During Acyl Transfer In Polyketide Biosynthesis.
- Manipulating posttranslational modification in natural product biosynthesis
- Synthesis and evaluation of transvalencin analogues and adenylation inhibitors as antitubercular agents and chemical probes
- Molekularbiologische Untersuchungen zur Biosynthese der Aminocoumarin-Antibiotika Clorobiocin und Coumermycin A1
- Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosis
- Cracking the resistance of non-tuberculosis mycobacterium against existing antibiotics
- Iron Acquisition by the Genus Mycobacterium
- Polyketide versatility in the biosynthesis of complex mycobacterial cell wall lipids.
- Molecular mechanisms of host-pathogen interaction: entry and survival of mycobacteria in macrophages.
- Nonribosomal biosynthesis of microbial chromopeptides.
- Non-ribosomal peptide synthetases as technological platforms for the synthesis of highly modified peptide bioeffectors--Cyclosporin synthetase as a complex example.
- IdeR is required for iron homeostasis and virulence in Mycobacterium tuberculosis
- Tuberculosis chemotherapy: recent developments and future perspectives.
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