The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation
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Summary
It is demonstrated that a selective blockade of the alternative pathway by neutralizing factor D in human serum diluted by pathway‐selective inhibitory mAbs inhibited more than 80% of C5a and TCC formation induced by solid phase IgM and solid‐ and fluid‐phase human aggregated IgG via the classical pathway.
- Type
- article
- Published
- 2004-12-01
- Cited by
- 343
- References
- 32
- Access
- Open access
- OpenAlex
- https://openalex.org/W1980493655
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24887441
Keywords
Alternative complement pathway, Lectin pathway, Classical complement pathway, Complement system, Complement factor B
References
- Complement. First of two parts.
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- Complement in inflammatory tissue damage and disease.
- Formation of High Affinity C5 Convertase of the Classical Pathway of Complement*
- Quantification in Enzyme‐Linked Immunosorbent Assay of a C3 Neoepitope Expressed on Activated Human Complement Factor C3
- Inhibition of complement, neutrophil, and platelet activation by an anti-factor D monoclonal antibody in simulated cardiopulmonary bypass circuits.
- Functional characterization of the lectin pathway of complement in human serum.
- The role of antibody in the activation of the alternative complement pathway
- Current concepts in immunology: the alternative pathway of complement--a system for host resistance to microbial infection.
- The mechanism of activation of the alternative pathway of complement by cell-bound C4b.
- The dark side of C5a in sepsis
- Regulation of Complement
- Binding of polymeric IgG to fibronectin in extracellular matrices: an in vitro paradigm for immune-complex deposition.
- Effects of complement factor D deficiency on the renal disease of MRL/lpr mice.
- THE PHLOGISTIC ROLE OF C3 LEUKOTACTIC FRAGMENTS IN MYOCARDIAL INFARCTS OF RATS
- Ischaemia–reperfusion is an event triggered by immune complexes and complement
- Complement system on the attack in autoimmunity.
- Production of monoclonal antibodies against the human anaphylatoxin C5a des Arg and their application in the neoepitope-specific sandwich-ELISA for the quantification of C5a des Arg in plasma.
- Formation of high-affinity C5 convertases of the alternative pathway of complement.
Cited by
- The role of complement in biomaterial-induced inflammation.
- Local production of the alternative pathway component factor B is sufficient to promote laser-induced choroidal neovascularization.
- Complement and Antibody-mediated Enhancement of Red Blood Cell Invasion and Growth of Malaria Parasites
- Mathematical Modelling of Alternative Pathway of Complement System
- Interactions between platelets and complement with implications for the regulation at surfaces
- Alginate Microcapsules for Cell Therapy : Effect of capsule composition on complement activation, cytokine secretion, and protein adsorption in a whole blood model
- Therapeutic control of complement activation at the level of the central component C3
- Identification of Peptidic Inhibitors of the Alternative Complement Pathway Based on Staphylococcus aureus SCIN Proteins
- Towards Immuno-profiling of Complex Biological Fluids in Patients Recovering from Major Surgery
- The role of complement properdin in murine infection with Listeria monocytogenes
- Rôles physiopathologiques du complément dans le syndrome coronarien aigu et implications thérapeutiques
- Complement factor H dysfunction in atypical hemolytic uremic syndrome
- Biological characterization of compounds from Rhinella schneideri poison that act on the complement system
- Complement factor H regulation in the central nervous system
- The influence of vitamin E bonded haemodialysis membranes on erythropoiesis stimulating agent requirements, oxidative stress, inflammation, haemostasis and outcomes
- Immunity in borreliosis with special emphasis on the role of complement.
- The Central Role of the Alternative Complement Pathway in Human Disease1
- Improved ex vivo blood compatibility of central venous catheter with noble metal alloy coating
- Staphylococcus epidermidis - virulence factors and innate immune response
- Properdin Provides Protection from Citrobacter rodentium–Induced Intestinal Inflammation in a C5a/IL-6–Dependent Manner
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