Caspase activity and a specific cytochrome C are required for sperm differentiation in Drosophila.
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Summary
It is shown that apoptotic proteins play an essential role during spermatid individualization in Drosophila melanogaster, and that a giant ubiquitin-conjugating enzyme, dBruce, is required to protect the sperm nucleus against hypercondensation and degeneration.
- Type
- article
- Published
- 2003-05-01
- Cited by
- 420
- References
- 59
- Access
- Open access
- OpenAlex
- https://openalex.org/W1980331623
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7163893
Keywords
Spermatid, Biology, Cell biology, Drosophila melanogaster, Sperm
References
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- Adult Apaf-1-deficient mice exhibit male infertility.
- Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms
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- A Giant Ubiquitin-conjugating Enzyme Related to IAP Apoptosis Inhibitors
- COLLAGEN CONTENT OF BARREN AND PREVIOUSLY PREGNANT UTERINE HORNS IN OLD MICE.
- The role of ARK in stress-induced apoptosis in Drosophila cells
- Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death
- Characterization of two Drosophila melanogaster cytochrome c genes and their transcripts.
Cited by
- Big wheel keeps on turning: apoptosome regulation and its role in chemoresistance
- The Role of Apoptosis-Induced Proliferation for Regeneration and Cancer
- Sublethal Caspase Activation Promotes Generation of Cardiomyocytes from Embryonic Stem Cells
- Protective effects of phloridzin against methotrexate-induced liver toxicity in rats.
- Detecting Caspase Activity in Drosophila Larval Imaginal Discs
- Caspase Cleavage of Gelsolin Is an Inductive Cue for Pathologic Cardiac Hypertrophy
- Cross-Species Comparison of Spermatocyte Responses to Induced DNA Damage: the Laboratory Mouse and Drosophila melanogaster
- Dissecting the function of Ack family kinases in Drosophila through understanding their interactions with Dock and Cdc42
- Hsp70 est un nouveau régulateur majeur de l'érythropoïèse empêchant le clivage du facteur de transcription GATA-1 par la caspase-3 au cours de la différenciation.
- Developmental and Neurogenetic Studies on the Peptidergic Nerve System in Drosophila
- Role of pluripotency factor NANOG in stratified epithelia and cancer
- To die or to differentiate: apoptotic and non-apoptotic roles of death molecules in Drosophila melanogaster
- Wnt signaling in the mouse heart: a role for Wnt11 in cardiogenesis
- Investigation of the FAT10 conjugation pathway
- Computational approaches to discovering differentiation genes in the peripheral nervous system of Drosophila melanogaster
- The role of the exoribonuclease Pacman/Xrn1 in wing development in Drosophila
- Male fertility and apoptosis in normal spermatogenesis are regulated by vacuolar-ATPase isoform a2.
- Beyond apoptosis: caspase regulatory mechanisms and functions in vivo
- Charakterisierung von BRUCE als antiapoptotisches IAP
- Caspase signaling in animal development
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