Brain 5-HT synthesis in the Flinders Sensitive Line rat model of depression: an autoradiographic study.
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Summary
Results suggest that significantly reduced 5-HT synthesis in the raphe nuclei and limbic areas in FSL rats may contribute to their depressive features.
- Type
- article
- Published
- 2006-04-01
- Cited by
- 67
- References
- 57
- OpenAlex
- https://openalex.org/W1979873771
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46361673
Keywords
Serotonergic, Endocrinology, Internal medicine, Serotonin, Dorsal raphe nucleus
References
- Serotonergic measures in suicide brain: 5-HT1A binding sites in frontal cortex of suicide victims
- Biology of schizophrenia and affective disease
- Stimulus‐specific plasticity of prefrontal cortex dopamine neurotransmission
- Regional brain serotonin synthesis is increased in the olfactory bulbectomy rat model of depression: an autoradiographic study
- Behavioral Characteristics of Rat Lines Selected for Differential Hypothermic Responses to Cholinergic or Serotonergic Agonists
- How does displacement of albumin-bound tryptophan cause sustained increases in the free tryptophan concentration in plasma and 5-hydroxytryptamine synthesis in brain?
- Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex.
- The olfactory bulbectomized rat as a model of depression: an update.
- Selective breeding for sensitivity to DFP: generalization of effects beyond criterion variables.
- A STUDY OF PROPOSED DETERMINANTS OF BRAIN TRYPTOPHAN CONCENTRATION IN RATS AFTER PORTOCAVAL ANASTOMOSIS OR SHAM OPERATION
- End product inhibition of serotonin synthesis in the rat striatum.
- CSF amine metabolites in depression.
- The effects of single dose nefazodone and paroxetine upon 5-HT2A binding potential in humans using [18F]-setoperone PET
- Effects of stress on the metabolism of noradrenaline, dopamine and serotonin (5HT) in the central nervous system of the rat. (II). Modifications of serotonin metabolism.
- Mood-lowering effect of tryptophan depletion. Enhanced susceptibility in young men at genetic risk for major affective disorders.
- High Serotonin and 5‐Hydroxyindoleacetic Acid Levels in Limbic Brain Regions in a Rat Model of Depression; Normalization by Chronic Antidepressant Treatment
- Elucidation of the neurobiology of depression: insights from a novel genetic animal model.
- Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression
- Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls.
- The electrophysiology of prefrontal serotonin systems: therapeutic implications for mood and psychosis.
Cited by
- Acetylcholine in Central Cardiorespiratory Regulation in Health and Depression
- Cortical brain release of glutamate by ketamine and fluoxetine: An in vivo microdialysis study in the Flinders Sensitive Line rat
- The long-term effects of fluoxetine on stress-related behaviour and acute monoaminergic stress response in stress sensitive rats
- Medial Forebrain Bundle Deep Brain Stimulation has Symptom-specific Anti-depressant Effects in Rats and as Opposed to Ventromedial Prefrontal Cortex Stimulation Interacts With the Reward System.
- Experiential and genetic contributions to depressive- and anxiety-like disorders: clinical and experimental studies.
- Serotonin 1A receptors and sexual behavior in a genetic model of depression.
- Antidepressants induce regionally discrete, sex-dependent changes in brain's glutamate content.
- Behavioral Characteristics of Pharmacologically Selected Lines of Rats: Relevance to Depression
- AGN-2979, an inhibitor of tryptophan hydroxylase activation, does not affect serotonin synthesis in Flinders Sensitive Line rats, a rat model of depression, but produces a significant effect in Flinders Resistant Line rats
- Increased autoimmune activity against 5-HT: a key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression.
- Genetic rodent models of depression.
- Affect-related Behaviors in Mice Misexpressing the RNA Editing Enzyme ADAR2
- Sex-related differential response to clomipramine treatment in a rat model of depression
- Arachidonic acid-containing phosphatidylcholine species are increased in selected brain regions of a depressive animal model: implications for pathophysiology.
- Impaired serotonergic regulation of heart rate may underlie reduced baroreflex sensitivity in an animal model of depression.
- The Flinders Sensitive Line of rats, a rat model of depression, has elevated brain glucose utilization when compared to normal rats and the Flinders Resistant Line of rats.
- Estrogenic mediation of serotonergic and neurotrophic systems: implications for female mood disorders.
- Antidepressant-like effects of 3,4-methylenedioxymethamphetamine in an animal model of depression
- The lumped constant of α-methyl-L-tryptophan is not influenced by drugs acting through serotonergic system
- The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression.
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