Stem cell differentiation requires a paracrine pathway in the heart
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Summary
Embryoid bodies generated from stem cells primed with these growth factors demonstrated an increased potential for cardiac differentiation with a significant increase in beating areas and enhanced myofibrillogenesis and in vivo, transplantation of stem cells into heart resulted in cardiac differentiation provided that TGF‐β/BMP2 signaling was intact.
- Type
- article
- Published
- 2002-10-01
- Cited by
- 520
- References
- 52
- OpenAlex
- https://openalex.org/W1979608640
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24742475
Keywords
Paracrine signalling, Cell biology, Stem cell, Chemistry, Biology
References
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- Changes in E2F complexes containing retinoblastoma protein family members and increased cyclin-dependent kinase inhibitor activities during terminal differentiation of cardiomyocytes.
- The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4.
- Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
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- Comparison of the effects of fetal cardiomyocyte and skeletal myoblast transplantation on postinfarction left ventricular function.
Cited by
- Reactive Oxygen Species as Signaling Molecules in Cardiovascular Differentiation of Embryonic Stem Cells and Tumor-Induced Angiogenesis
- Heart repair and stem cells
- Gene and cell therapy for chronic ischaemic heart disease
- Generation of Functional Cardiomyocytes From Adult Mouse Spermatogonial Stem Cells
- Genetic selection of cardiomyocytes from human embryonic stem cells.
- Layer-by-layer films as a biomimetic reservoir for rhBMP-2 delivery: controlled differentiation of myoblasts to osteoblasts.
- Combinatorial Polymer Electrospun Matrices Promote Physiologically-Relevant Cardiomyogenic Stem Cell Differentiation
- The Influence of Leukemia Inhibitory Factor on Cardiomyogenesis
- Embryonic Stem Cell Transplantation
- Cardiac stem cells and progenitors: developmental biology and therapeutic challenges.
- Embryonic and adult stem cell-derived cardiomyocytes: lessons from in vitro models.
- Estudio aleatorizado de la terapia celular en el infarto agudo de miocardio : análisis de los efectos proliferativos de la terapia celular sobre la proliferación intimal y la aterosclerosis coronaria
- Stem Cells and Herbal Acupuncture Therapy
- Adipose-derived stem cells and their cardiogenic differentiation
- The Transcriptomic Profiling Of Murine Embryonic Stem Cell-derived Mesodermal Cell Lineages And Functional Cardiomyocytes: An Insight Into Mesodermal Patterning
- Reactive oxygen species and upregulation of NADPH oxidases in mechanotransduction of embryonic stem cells.
- Wnt signaling and cardiac differentiation.
- Cardiovascular development: towards biomedical applicability
- Skeletal myoblast for cell therapy.
- Regeneration gaps: observations on stem cells and cardiac repair.
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