A Study on the Effect of Wet Granulation on Microcrystalline Cellulose Particle Structure and Performance
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Summary
Under certain conditions, milling seems to counteract the effect of wet granulation on MCC compactibility, which is associated with the decrease in MCC primary particle porosity and in some cases with the formation of large dense granules as well.
- Type
- article
- Published
- 2005-01-01
- Cited by
- 66
- References
- 17
- OpenAlex
- https://openalex.org/W1979535436
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26020382
Keywords
Granulation, Microcrystalline cellulose, Compaction, Porosity, Materials science
References
- Water sorption and near IR spectroscopy to study the differences between microcrystalline cellulose and silicified microcrystalline cellulose before and after wet granulation.
- The interactions of water with cellulose- and starch-derived pharmaceutical excipients
- The Crystallite-Gel-Model for Microcrystalline Cellulose in Wet-Granulation, Extrusion, and Spheronization
- Crystallinity and Physical Characteristics of Microcrystalline Cellulose. II. Fine Structure of Ground Microcrystalline Cellulose
- Microcrystalline Cellulose as a Sponge as an Alternative Concept to the Crystallite-Gel Model for Extrusion and Spheronization
- Effect of addition of water on the rheological and mechanical properties of microcrystalline celluloses
- Compression characteristics of granulated materials. IV. The effect of granule porosity on the fragmentation propensity and the compatibility of some granulations
- Particle analysis of microcrystalline cellulose: Differentiation between individual particles and their agglomerates
- Microcrystalline cellulose and its microstructure in pharmaceutical processing.
- Compression behaviour and compactability of microcrystalline cellulose pellets in relationship to their pore structure and mechanical properties
- Evaluation of Surface and Bulk Characteristics of Cellulose I Powders in Relation to Compaction Behavior and Tablet Properties
- The change in characteristics of microcrystalline cellulose during wet granulation using a high‐shear mixer
- Differences in the mechanical strength of dried microcrystalline cellulose pellets are not due to significant changes in the degree of hydrogen bonding.
- Effect of process parameters on compressibility of granulation manufactured in a high-shear mixer.
- Crystallinity and physical characteristics of microcrystalline cellulose.
Cited by
- Roles of granule size in over-granulation during high shear wet granulation.
- Scanning probe microscopy in the field of drug delivery.
- A formulation strategy for solving the overgranulation problem in high shear wet granulation.
- Importance of excipient wettability on tablet characteristics prepared by moisture activated dry granulation (MADG).
- Role of drug substance material properties in the processibility and performance of a wet granulated product.
- Origin of profound changes in powder properties during wetting and nucleation stages of high-shear wet granulation of microcrystalline cellulose
- Comparison of granule properties produced using Twin Screw Extruder and High Shear Mixer: A step towards understanding the mechanism of twin screw wet granulation
- Importance of evaluating the consolidation of granules manufactured by high shear mixer.
- A combined experimental and modeling approach to study the effects of high-shear wet granulation process parameters on granule characteristics
- Evaluation of the physical and mechanical properties of high drug load formulations: Wet granulation vs. novel foam granulation
- Materials science tetrahedron--a useful tool for pharmaceutical research and development.
- Mechanistic basis for the effects of process parameters on quality attributes in high shear wet granulation.
- Effect of spray-dried mannitol on the performance of microcrystalline cellulose-based wet granulated tablet formulation
- The Relationship between the Micromeritic Properties of Mixture and Raw Materials: Microcrystalline Cellulose and Herba sarcandrae Extract
- Characterisation of the interactive properties of microcrystalline cellulose-carboxymethyl cellulose hydrogels.
- Twin screw wet granulation: Influence of formulation parameters on granule properties and growth behavior
- Investigation of solution and vapor phase mediated phase transformation in thiamine hydrochloride.
- Modified celluloses as multifunctional excipients in rapidly dissolving immediate release tablets
- Initial moisture content in raw material can profoundly influence high shear wet granulation process.
- Evolution of structure and properties of granules containing microcrystalline cellulose and polyvinylpyrrolidone during high-shear wet granulation.
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