Vi antigen biosynthesis in Salmonella typhi: characterization of UDP-N-acetylglucosamine C-6 dehydrogenase (TviB) and UDP-N-acetylglucosaminuronic acid C-4 epimerase (TviC).
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Summary
The results show that the biosynthesis of Vi antigen is initiated by the TviB-catalyzed oxidation of UDP-GlcNAc to UDP-GalNAc, followed by theTviC- catalyzed epimerization at C-4 to form UDP- GalNAcA, which serves as the building block for the formation of Vi polymer.
- Type
- article
- Published
- 2006-07-04
- Cited by
- 30
- References
- 30
- Access
- Open access
- OpenAlex
- https://openalex.org/W1979081124
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19078965
Keywords
Salmonella typhi, Biosynthesis, Microbiology, Salmonella, Enzyme
References
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- The VI Antigens of the Enterobacteriaceae II. Immunologic and Biologic Properties
- Genetic Mapping of Vi and Somatic Antigenic Determinants in Salmonella
- Active site residues and mechanism of UDP-glucose dehydrogenase.
- Genetic Transfer of the Vi Antigen from Salmonella typhosa to Escherichia coli
- Complete nucleotide sequence and molecular characterization of ViaB region encoding Vi antigen in Salmonella typhi
- Molecular structure of the NADH/UDP-glucose abortive complex of UDP-galactose 4-epimerase from Escherichia coli: implications for the catalytic mechanism.
- On the Vi antigen of Salmonella typhi.
- Immunogenicity, efficacy and serological correlate of protection of Salmonella typhi Vi capsular polysaccharide vaccine three years after immunization.
- Properties and Kinetic Analysis of UDP-glucose Dehydrogenase from Group A Streptococci
- Virulence of B. typhosus and Resistance to O Antibody.
- Identification of six open reading frames in the Salmonella enterica subsp. enterica ser. Typhi viaB locus involved in Vi antigen production.
- Crystal structures of the oxidized and reduced forms of UDP-galactose 4-epimerase isolated from Escherichia coli.
- Biochemical Characterization of WbpA, a UDP-N-acetyl-d-glucosamine 6-Dehydrogenase Involved in O-antigen Biosynthesis in Pseudomonas aeruginosa PAO1*
- Molecular characterization of microbial alcohol dehydrogenases.
- New UDP-GlcNAc C4 epimerase involved in the biosynthesis of 2-acetamino-2-deoxy-L-altruronic acid in the O-antigen repeating units of Plesiomonas shigelloides O17.
- Expression, Purification, and Biochemical Characterization of WbpP, a New UDP-GlcNAc C4 Epimerase from Pseudomonas aeruginosa Serotype O6*
- Towards a better understanding of the substrate specificity of the UDP-N-acetylglucosamine C4 epimerase WbpP.
Cited by
- Analyses of the proteins KpsM, KpsE and KpsD in the group 2 capsular polysaccharide export complex of Escherichia coli
- Enzymatic analysis of uridine diphosphate N-acetyl-D-glucosamine.
- From bench to bedside: stealth of enteroinvasive pathogens
- Molecular Characterization of the viaB Locus Encoding the Biosynthetic Machinery for Vi Capsule Formation in Salmonella Typhi
- Variation in the Complex Carbohydrate Biosynthesis Loci of Acinetobacter baumannii Genomes
- A gold nanoparticles based immuno-bioprobe for detection of Vi capsular polysaccharide of Salmonella enterica serovar Typhi.
- Optimization of Vi capsular polysaccharide production during growth of Salmonella enterica serotype Typhi Ty2 in a bioreactor.
- Comparative Genomic and Transcriptomic Analysis of Wangiella dermatitidis, A Major Cause of Phaeohyphomycosis and a Model Black Yeast Human Pathogen
- Structural characterization of enzymatic products in the dTDP-d-Qui4NFo biosynthetic pathway using electrospray ionization tandem mass spectrometry.
- Transcriptional Regulation of the Escherichia coli Gene rraB, Encoding a Protein Inhibitor of RNase E
- Identification of the UDP-N-Acetylglucosamine 4-Epimerase Involved in Exosporium Protein Glycosylation in Bacillus anthracis
- Acetamido Sugar Biosynthesis in the Euryarchaea
- Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype Typhi
- Characterizing properties of bacterial outer membrane polysaccharide export (OPX) proteins
- Survival of the Fittest: How Bacterial Pathogens Utilize Bile To Enhance Infection
- Characterization and Comparative Overview of Complete Sequences of the First Plasmids of Pandoraea across Clinical and Non-clinical Strains
- Vi capsular polysaccharide: Synthesis, virulence, and application
- Biosynthesis and Assembly of the Vi Antigen Capsule Produced by Salmonella enterica serovar Typhi
- Why Is Eradicating Typhoid Fever So Challenging: Implications for Vaccine and Therapeutic Design
- Sewage effluent from an Indian hospital harbors novel carbapenemases and integron-borne antibiotic resistance genes
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