A lipidomic platform establishment for structural identification of skin ceramides with non-hydroxyacyl chains
Explore this paper's citation graph
Summary
Based on established MS/MS fragmentation patterns of N-type ceramides, 52 ceramide classes (including different classes of NS, NdS, NP, and NH) were identified in human SC and mass fragmentation patterns, which were found in higher m/z regions of tandem mass spectra, could be applied to structural identification of ceramids.
- Type
- article
- Published
- 2014-01-24
- Cited by
- 27
- References
- 26
- OpenAlex
- https://openalex.org/W1979080173
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37538112
Keywords
Ceramide, Sphingolipid, Chemistry, Sphingosine, Fatty acid
References
- Determination of stratum corneum lipid profile by tape stripping in combination with high-performance thin-layer chromatography
- Quantities and types of ceramides and their relationships to physical properties of the horn covering the claws of clinically normal cows and cows with subclinical laminitis.
- Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema
- Separation and mass spectrometric characterization of covalently bound skin ceramides using LC/APCI-MS and Nano-ESI-MS/MS.
- Epidermal sphingolipids: Metabolism, function, and roles in skin disorders
- Alkaline methanolysis of lipid extracts extends shotgun lipidomics analyses to the low-abundance regime of cellular sphingolipids.
- Profiling and characterizing skin ceramides using reversed-phase liquid chromatography-quadrupole time-of-flight mass spectrometry.
- Development and validation of LC/ESI-MS method for the detection and quantification of exogenous ceramide NP in stratum corneum and other layers of the skin.
- Metabonomics research of diabetic nephropathy and type 2 diabetes mellitus based on UPLC-oaTOF-MS system.
- LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery[S]
- Characterization and direct quantitation of ceramide molecular species from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry.
- Investigation of the Molecular Structure of the Human Stratum Corneum Ceramides [NP] and [EOS] by Mass Spectrometry
- Ceramide profiling of complex lipid mixtures by electrospray ionization mass spectrometry.
- Liquid chromatography–electrospray mass spectrometry and tandem mass spectrometry of ceramides
- Comparative investigation of human stratum corneum ceramides
- Characterization of ceramides by low energy collisional-activated dissociation tandem mass spectrometry with negative-ion electrospray ionization
- Ceramide biosynthesis in keratinocyte and its role in skin function.
- Long-term performance and stability of molecular shotgun lipidomic analysis of human plasma samples.
- Ceramide composition of the psoriatic scale.
- Human stratum corneum lipids: characterization and regional variations.
Cited by
- Changing in lipid profile induced by the mutation of Foxn1 gene: A lipidomic analysis of Nude mice skin.
- A metabolomics approach shows that catechin-enriched green tea attenuates ultraviolet B-induced skin metabolite alterations in mice
- Advances in sample preparation and analytical techniques for lipidomics study of clinical samples
- Lipidomic platform for structural identification of skin ceramides with α-hydroxyacyl chains
- Stratum Corneum Lipids: Their Role for the Skin Barrier Function in Healthy Subjects and Atopic Dermatitis Patients.
- Lipidomic analysis of epidermal lipids: a tool to predict progression of inflammatory skin disease in humans
- Quantitative analysis of ceramides using a novel lipidomics approach with three dimensional response modelling.
- Structural identification of skin ceramides containing ω-hydroxy acyl chains using mass spectrometry
- As in Atopic Dermatitis, Nonlesional Skin in Allergic Contact Dermatitis Displays Abnormalities in Barrier Function and Ceramide Content.
- Sulfatides Primarily Exist in the Substantia Nigra Region of Mouse Brain Tissue
- Large-scale human skin lipidomics by quantitative, high-throughput shotgun mass spectrometry
- Identification of the ligand of Pru p 3, a peach LTP
- Integrative metabolomic analysis reveals diet supplementation with green tea alleviates UVB-damaged mouse skin correlated with ascorbate metabolism and urea cycle
- Influence of the sebaceous gland density on the stratum corneum lipidome
- LC‐MS analysis of key components of the glutathione cycle in tissues and body fluids from mice with myocardial infarction
- Identification of lipids of the stratum corneum by high performance thin layer chromatography and mass spectrometry
- Lipidomic analysis as a tool for identifying susceptibility to various skin diseases
- Decrease of ceramides with long‐chain fatty acids in psoriasis: Possible inhibitory effect of interferon gamma on chain elongation
- Methodological Considerations for Lipid and Polar Component Analyses in Human Skin Stratum Corneum
- Role of Omega-Hydroxy Ceramides in Epidermis: Biosynthesis, Barrier Integrity and Analyzing Method
Related papers
- Biophysical properties of sphingosine, ceramides and other simple sphingolipids.
- Induction of apoptosis by sphingosine, sphinganine, and C(2)-ceramide in human colon cancer cells, but not by C(2)-dihydroceramide.
- Sphingolipid metabolic changes during chiral C2-ceramides induced apoptosis in human leukemia cells
- Sphingolipid signaling pathways as potential therapeutic targets in gliomas.
- Ceramide synthase.
- Novel Agents Targeting Bioactive Sphingolipids for the Treatment of Cancer
- Novel Agents Targeting Bioactive Sphingolipids for the Treatment of Cancer
- Novel agents targeting bioactive sphingolipids for the treatment of cancer.
- Sphingomyelin synthase inhibition in sarcomas results in ceramide accumulation and apoptosis
- Deregulation of sphingolipid metabolism in Alzheimer's disease.