Nitric oxide therapy For cardiovascular disease
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Summary
The endogenous NO pathway can now be therapeutically modulated to optimise endothelial or peripheral neuronal vasodilator function by inhibiting PDEV and may be clinically viable through the supplementation of precursors and cofactors of NO synthesis, the upregulation of endothelial NO synthase (eNOS) and the transfection of NOS genes to the vasculature.
- Type
- article
- Published
- 2001-06-01
- Cited by
- 5
- References
- 64
- OpenAlex
- https://openalex.org/W1978512928
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:93404551
Keywords
Enos, Downregulation and upregulation, Endothelial dysfunction, Nitric oxide, Nitric oxide synthase
References
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- Sildenafil
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- Asymmetric Dimethylarginine, Derangements of the Endothelial Nitric Oxide Synthase Pathway, and Cardiovascular Diseases
- Microassay of superoxide anion scavenging activity in vitro.
- Positive and negative outcomes of L-arginine therapy in cardiovascular diseases.
- Nitric oxide in the lung: therapeutic and cellular mechanisms of action.
- Nitric oxide synthases in mammals.
- Nitric oxide: discovery and impact on clinical medicine
- Nitric oxide (NO)-related pharmaceuticals: contemporary approaches to therapeutic NO modulation.
- Endothelial cell dysfunction and the pathogenesis of diabetic macroangiopathy
- Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion.
- Pharmacological modulation of nitric oxide synthesis by mechanism-based inactivators and related inhibitors.
- Role of nitrates for the therapy of coronary artery disease patients in the years beyond 2000.
- Evidence for a causal role of the renin-angiotensin system in nitrate tolerance.
- Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension.
- Transfer and expression of recombinant nitric oxide synthase genes in the cardiovascular system.
- Nitroglycerin Tolerance in Human Vessels: Evidence for Impaired Nitroglycerin Bioconversion
- Absence of nitrate tolerance after long-term treatment with ramipril: an endothelium-dependent mechanism.
- Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.
Cited by
- Pharmaceutical compositions for antihypertensive treatments: a patent review
- Nitric oxide donor drugs: current status and future trends
- Future anti-inflammatory metabolic and cardiovascular management of Type 2 diabetes mellitus
- Therapeutic approaches to the management of dysmetabolic cardiovascular disease
- Organic nitrate-induced oxidant stress and cardiovascular therapy
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