Tipping the Balance: Robustness of Tip Cell Selection, Migration and Fusion in Angiogenesis
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Summary
The development and implementation of a novel physics-based hierarchical agent model, tightly coupled to in vivo data, and down-regulation of the migratory pathway alone is shown to be sufficient to rescue the sprouting system from oscillation and restore stability are described.
- Type
- article
- Published
- 2009-10-01
- Cited by
- 201
- References
- 65
- Access
- Open access
- OpenAlex
- https://openalex.org/W1978393368
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17075693
Keywords
Filopodia, Cell biology, Angiogenesis, Cell, Lateral inhibition
References
- Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors.
- Pattern formation by lateral inhibition with feedback: a mathematical model of delta-notch intercellular signalling.
- Hypoxia-regulated differentiation: let's step it up a Notch.
- Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
- Mechanisms of angiogenesis
- New insights into intussusceptive angiogenesis.
- How nematode sperm crawl.
- p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells
- Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
- Reduced expression of actin‐binding proteins, h‐caldesmon and calponin h1, in the vascular smooth muscle inside melanoma lesions: an adverse prognostic factor for malignant melanoma
- Towards a regional approach to cell mechanics.
- Synthetic biology: The yin and yang of nature
- Multiscale biosystems integration: Coupling intracellular network analysis with tissue-patterning simulations
- From in vivo to in silico biology and back
- Morphogenesis of lines and nets.
- Retinal angiogenesis in development and disease
- Computational Model of VEGF Spatial Distribution in Muscle and Pro-Angiogenic Cell Therapy
- Mathematical modelling of dynamic adaptive tumour-induced angiogenesis: clinical implications and therapeutic targeting strategies.
- Agent-based simulation of notch-mediated tip cell selection in angiogenic sprout initialisation.
- Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38
Cited by
- Angiopoietins in angiogenesis.
- Cellular and physical mechanisms of branching morphogenesis
- Classical and non-classical proangiogenic factors as a target of antiangiogenic therapy in tumor microenvironment.
- Therapeutic angiogenesis: angiogenic growth factors for ischemic heart disease.
- Computational Screening of Tip and Stalk Cell Behavior Proposes a Role for Apelin Signaling in Sprout Progression
- Multiscale modelling of cancer cell motility
- Vascular development: genetic mechanisms and links to vascular disease.
- Cell migration and capillary plexus formation in wounds and retinae
- Stem Cells and Their Niches in Angiogenesis: Vascular Endothelial Stem Cells, Hematopoietic Progenitors and Hematopoietic Effector Cells
- The Force at the Tip - Modelling Tension and Proliferation in Sprouting Angiogenesis
- VEGFR3 and Notch signaling in angiogenesis
- Agent-based modeling of porous scaffold degradation and vascularization: Optimal scaffold design based on architecture and degradation dynamics.
- Computational modeling and simulation of cellular growth and migration in angiogenesis
- Notch signaling in the vasculature
- Integrative modelling of angiogenesis in the bovine corpus luteum
- Single cell decisions in endothelial population in the context of inflammatory angiogenesis
- Essential Roles of EphB Receptors and EphrinB Ligands in Endothelial Cell Function and Angiogenesis
- VEGF and NOTCH in blood vessels, an intricate and fascinating interplay
- Analysis of an fih mutation in the zebrafish
- Endothelial cell motility, coordination and pattern formation during vasculogenesis
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