The Butenolide Signaling Molecules SRB1 and SRB2 Induce Lankacidin and Lankamycin Production in Streptomyces rochei
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Summary
The synthetic 1′R isomers induced production of lankacidin and lankamycin at around 40 nM concentrations are therefore distinct from the well‐known 2,3‐disubstituted γ‐butyrolactone molecules such as A‐factor, virginia butanolide, and SCB1 and belong, like avenolide, recently isolated from Streptomyces avermitilis, to the γ-butenolide family.
- Type
- article
- Published
- 2012-07-09
- Cited by
- 64
- References
- 56
- OpenAlex
- https://openalex.org/W1977953990
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29529744
Keywords
Butenolide, Streptomyces, Sephadex, Stereochemistry, High-performance liquid chromatography
References
- γ-Butyrolactone-Dependent Expression of the Streptomyces Antibiotic Regulatory Protein Gene srrY Plays a Central Role in the Regulatory Cascade Leading to Lankacidin and Lankamycin Production in Streptomyces rochei
- The large linear plasmid pSLA2‐L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism
- Lactone chemistry. Synthesis of .beta.-substituted, .gamma.-functionalized butan- and butenolides and succinaldehydic acids from glyoxylic acid
- Identification of an AfsA homologue (BarX) from Streptomyces virginiae as a pleiotropic regulator controlling autoregulator biosynthesis, virginiamycin biosynthesis and virginiamycin M1 resistance
- Analysis of two additional signaling molecules in Streptomyces coelicolor and the development of a butyrolactone-specific reporter system.
- Branched-chain fatty acid requirement for avermectin production by a mutant of Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity.
- Synthesis of enantiomerically pure γ-(menthyloxy)butenolides and (R)- and (S)-2-methyl-1,4-butanediol
- High-field FT NMR application of Mosher's method. The absolute configurations of marine terpenoids
- Gene Replacement Analysis of the Butyrolactone Autoregulator Receptor (FarA) Reveals that FarA Acts as a Novel Regulator in Secondary Metabolism of Streptomyces lavendulae FRI-5
- Isolation and characterization of linear plasmids from lankacidin-producing Streptomyces species.
- Production of butyrolactone autoregulators by Streptomyces coelicolor A3(2)
- 2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining
- The A‐factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus : identification of a target gene of the A‐factor receptor
- Butyrolactone Autoregulataors, Inducers of Secondary Metabolites, in Streptomyces
- Cyclization mechanism for the synthesis of macrocyclic antibiotic lankacidin in Streptomyces rochei.
- Biosynthesis of γ-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces
- Biosynthesis of Virginiae Butanolide A, a Butyrolactone Autoregulator from Streptomyces
- AdpA, a Central Transcriptional Regulator in the A-Factor Regulatory Cascade That Leads to Morphological Development and Secondary Metabolism in Streptomyces griseus
- Mutants blocked in streptomycin production in Streptomyces griseus - the role of A-factor.
- Regulation of Lankamycin Biosynthesis in Streptomyces rochei by Two SARP Genes, srrY and srrZ
Cited by
- Streptomyces euryhalinus sp. nov., a new actinomycete isolated from a mangrove forest
- Development of New reporter systems for studying gamma butyrolactone mediated signaling in streptomyces
- Biodiscovery of natural products from microbes associated with Irish coastal sponges
- Exogenous 1,4‐butyrolactone stimulates A‐factor‐like cascade and validamycin biosynthesis in Streptomyces hygroscopicus 5008
- Blockage of the early step of lankacidin biosynthesis caused a large production of pentamycin, citreodiol and epi-citreodiol in Streptomyces rochei
- The International Conference of Natural Product Biosynthesis (ICNPB, 8th US–Japan seminar on the Biosynthesis of Natural Products)
- Biosynthesis of polyketides by trans-AT polyketide synthases.
- Genetic and biochemical analysis of the antibiotic biosynthetic gene clusters on the Streptomyces linear plasmid
- Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products.
- Pseudonocardides A – G, New γ‐Butyrolactones from Marine‐derived Pseudonocardia sp. YIM M13669
- Overproduction and identification of butyrolactones SCB1-8 in the antibiotic production superhost Streptomyces M1152.
- Specialised metabolites regulating antibiotic biosynthesis in Streptomyces spp.
- Characterization of AvaR1, a butenolide-autoregulator receptor for biosynthesis of a Streptomyces hormone in Streptomyces avermitilis
- Regulatory mechanisms for production of secondary metabolites by Streptomyces hormones
- Discovering potential Streptomyces hormone producers by using disruptants of essential biosynthetic genes as indicator strains
- AvaR1, a Butenolide-Type Autoregulator Receptor in Streptomyces avermitilis, Directly Represses Avenolide and Avermectin Biosynthesis and Multiple Physiological Responses
- Manipulation of metabolic pathways controlled by signaling molecules, inducers of antibiotic production, for genome mining in Streptomyces spp.
- Chemical Elicitors of Antibiotic Biosynthesis in Actinomycetes
- Identification of a butenolide signaling system that regulates nikkomycin biosynthesis in Streptomyces
- A3 foresight network on natural products
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