The Butenolide Signaling Molecules SRB1 and SRB2 Induce Lankacidin and Lankamycin Production in Streptomyces rochei

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Summary

The synthetic 1′R isomers induced production of lankacidin and lankamycin at around 40 nM concentrations are therefore distinct from the well‐known 2,3‐disubstituted γ‐butyrolactone molecules such as A‐factor, virginia butanolide, and SCB1 and belong, like avenolide, recently isolated from Streptomyces avermitilis, to the γ-butenolide family.

Type
article
Published
2012-07-09
Cited by
64
References
56

Keywords

Butenolide, Streptomyces, Sephadex, Stereochemistry, High-performance liquid chromatography

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