Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits.
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Summary
Immuno-cytochemical analyses reveal the presence of protein modified by malondialdehyde, a peroxidative end product, which colocalizes with the extracellular deposition of apolipoprotein B-100 protein of LDL in atheroma from Watanabe heritable hyperlipidemic rabbits, providing direct evidence for the existence in vivo ofprotein modified by a physiological product of lipid peroxidation within arterial lesions.
- Type
- article
- Published
- 1988-07-08
- Cited by
- 736
- References
- 32
- OpenAlex
- https://openalex.org/W1977778060
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26750108
Keywords
Malondialdehyde, Atheroma, Lipid peroxidation, Chemistry, Scavenger receptor
References
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Cited by
- Mechanisms of atherosclerosis: role of LDL oxidation.
- The Role of Vitamin E and Carotenoids in Preventing Oxidation of Low Density Lipoproteins a
- Pathobiochemical changes of the arterial wall at the inception of atherosclerosis.
- Action of vitamin E as antioxidant against oxidative modification of low density lipoprotein
- Immunization of LDL receptor-deficient mice with homologous malondialdehyde-modified and native LDL reduces progression of atherosclerosis by mechanisms other than induction of high titers of antibodies to oxidative neoepitopes.
- The Processing of Ligands by the Class A Scavenger Receptor Is Dependent on Signal Information Located in the Cytoplasmic Domain*
- 新しい動脈硬化のバイオマーカー開発 : 新しいプロテオーム技術を用いて(3.動脈硬化のバイオマーカーの臨床的意義, 第76回日本循環器学会学術集会)
- Immunohistochemical distribution of lipoprotein epitopes in xanthomata from patients with familial hypercholesterolemia.
- Macrophage colony-stimulating factor mRNA and protein in atherosclerotic lesions of rabbits and humans.
- Development of atherosclerosis in the diabetic BALB/c mice. Prevention with Vitamin E administration.
- Effect of starvation stress on lipid peroxidation and lipid profile in rabbits.
- L’alimentation, le stress oxydatif : Sources de lipoperoxydation, comment s’en protéger
- Induction of chemotactic cytokines by minimally oxidized LDL.
- Oli de peix i producció vascular d'òxid nítric: possible paper protector en les lipoproteïnes
- Nutritional modulation of oxygen radical pathology.
- Inhibition of LDL oxidation by antioxidants.
- Circulating immune complexes in atherosclerotic vascular disease
- Minimally oxidized low-density lipoprotein induces tissue factor expression in cultured human endothelial cells.
- Dietary antioxidants, cancer, and atherosclerotic heart disease.
- Why are low-density lipoproteins atherogenic?
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