Aversive behavior induced by optogenetic inactivation of ventral tegmental area dopamine neurons is mediated by dopamine D2 receptors in the nucleus accumbens
Explore this paper's citation graph
Summary
It is reported that optogenetic inactivation of VTA DA neurons promptly down-regulated DA levels and induced up-regulation of the neural activity in the nucleus accumbens (NAc) as evaluated by Fos expression.
- Type
- article
- Published
- 2014-04-15
- Cited by
- 150
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W1977708746
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20735680
Keywords
Ventral tegmental area, Nucleus accumbens, Optogenetics, Dopamine, Neuroscience
References
- D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
- Subsecond reward-related dopamine release in the mouse dorsal striatum.
- GABA Neurons of the VTA Drive Conditioned Place Aversion
- Distinct roles of synaptic transmission in direct and indirect striatal pathways to reward and aversive behavior.
- Dynamic Dopamine Modulation in the Basal Ganglia: A Neurocomputational Account of Cognitive Deficits in Medicated and Nonmedicated Parkinsonism
- Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli
- Role of dopamine receptor mechanisms in the amygdaloid modulation of fear and anxiety: Structural and functional analysis.
- Neuron-type specific signals for reward and punishment in the ventral tegmental area
- Distinct roles for direct and indirect pathway striatal neurons in reinforcement
- Mesolimbic dopaminergic pathways in fear conditioning.
- Activation of VTA GABA neurons disrupts reward consumption
- Synaptic plasticity in dorsal striatal circuits controlling ynaptic action selection
- Social defeat stress selectively alters mesocorticolimbic dopamine release: an in vivo microdialysis study.
- Dopamine, learning and motivation
- High-Performance Genetically Targetable Optical Neural Silencing via Light-Driven Proton Pumps
- Resolving neurotransmitters detected by fast-scan cyclic voltammetry.
- Dopamine is Necessary for Cue-Dependent Fear Conditioning
- Uniform Inhibition of Dopamine Neurons in the Ventral Tegmental Area by Aversive Stimuli
- Activation of Dopamine Neurons is Critical for Aversive Conditioning and Prevention of Generalized Anxiety
- Dopamine receptors in canine caudate nucleus
Cited by
- VTA dopaminergic neurons regulate ethologically relevant sleep–wake behaviors
- Lesch-Nyhan Syndrome: Models, Theories, and Therapies
- Role of the Nucleus Accumbens and Mesolimbic Dopamine System in Modulating the Memory of Social Defeat in Male Syrian Hamsters (Mesocricetus auratus)
- Drug Predictive Cues Activate Aversion-Sensitive Striatal Neurons That Encode Drug Seeking
- Habenula lesions reveal that multiple mechanisms underlie dopamine prediction errors
- Reward-Induced Phasic Dopamine Release in the Monkey Ventral Striatum and Putamen
- Resting state functional connectivity analysis for addiction medicine: From individual loci to complex networks.
- Association between ANKK1 (rs1800497) polymorphism of DRD2 gene and attention deficit hyperactivity disorder: a meta-analysis.
- Comparison of c-Fos expression in brain regions involved in maternal behavior of virgin and lactating female mice.
- Role of nicotinic acetylcholine receptors in regulating dopamine neuron activity.
- Aversive stimuli drive drug seeking in a state of low dopamine tone
- A Role for Phasic Dopamine Release within the Nucleus Accumbens in Encoding Aversion: A Review of the Neurochemical Literature
- Optical suppression of drug-evoked phasic dopamine release
- Role of PKA signaling in D2 receptor-expressing neurons in the core of the nucleus accumbens in aversive learning
- Diversity of Transgenic Mouse Models for Selective Targeting of Midbrain Dopamine Neurons
- The Brain on Drugs: From Reward to Addiction.
- Cannabinoid modulation of drug reward and the implications of marijuana legalization
- Spontaneous eye blink rate predicts learning from negative, but not positive, outcomes.
- Striatal direct and indirect pathways control decision-making behavior
- Role of dopamine D2 receptors in optimizing choice strategy in a dynamic and uncertain environment
Related papers
- Optogenetic Activation of the Excitatory Neurons Expressing CaMKIIα in the Ventral Tegmental Area Upregulates the Locomotor Activity of Free Behaving Rats
- Disruptions in effort-based decision-making following acute optogenetic stimulation of ventral tegmental area dopamine cells
- Acute Aversive Stimuli Rapidly Increase the Activity of Ventral Tegmental Area Dopamine Neurons in Awake Mice.
- Dopamine D1 receptor; dopamine D2 receptor
- Chronic treatment with dopamine receptor antagonists: behavioral and pharmacologic effects on D1 and D2 dopamine receptors
- Genotypic differences in brain dopamine receptor function in the DBA/2J and C57BL/6J inbred mouse strains.
- Duration of Inhibition of Ventral Tegmental Area Dopamine Neurons Encodes a Level of Conditioned Fear
- Dopamine D2 receptor-mediated inhibition of neuronal activity in the ventral tegmental area in vitro
- Haloperidol-induced catalepsy is absent in dopamine D(2), but maintained in dopamine D(3) receptor knock-out mice.