Protein Folding Requires Crowd Control in a Simulated Cell
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Summary
The results suggest that the ability of small protein domains to fold without the help of chaperones may be an important factor in limiting the degree of macromolecular crowding in the cell.
- Type
- article
- Published
- 2010-04-16
- Cited by
- 97
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W1977157584
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29462336
Keywords
Macromolecular crowding, Crowding, Protein folding, Chaperone (clinical), Folding (DSP implementation)
References
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- The Kepler conjecture
- Can correct protein models be identified?
- Computer simulation of protein folding
- 15N NMR spin relaxation dispersion study of the molecular crowding effects on protein folding under native conditions.
- A model of intracellular organization
- Topological accessibility shows a distinct asymmetry in the folds of betaalpha proteins.
- Blind test of physics-based prediction of protein structures.
- How evolutionary pressure against protein aggregation shaped chaperone specificity.
- Folding, Stability and Shape of Proteins in Crowded Environments: Experimental and Computational Approaches
- Assessment of CASP7 structure predictions for template free targets
- Macromolecular crowding perturbs protein refolding kinetics: implications for folding inside the cell
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- PRIMO: An Interactive Homology Modeling Pipeline
- Investigation of protein-protein interactions: multibody docking, association/dissociation kinetics and macromolecular crowding
- Genome-wide characterization and expression analysis of common bean bHLH transcription factors in response to excess salt concentration
- Structural modeling and in silico analysis of non-synonymous single nucleotide polymorphisms of human 3β-hydroxysteroid dehydrogenase type 2
- The Phyre2 web portal for protein modelling, prediction and analysis
- Identification, molecular characterization and expression analysis of RPL24 genes in three Cucurbitaceae family members: cucumber, melon and watermelon
- Bioinformatic characterization of aspartic protease (AP) enzyme in seed plants
- Exact methods for lattice protein models
- Macromolecular Crowding Meets Tissue Engineering by Self‐Assembly: A Paradigm Shift in Regenerative Medicine
- Revisiting Disrupted-in-Schizophrenia 1 as a scaffold protein
- Resisting resistant Mycobacterium tuberculosis naturally: mechanistic insights into the inhibition of the parasite's sole signal peptidase Leader peptidase B.
- In Silico Determination and Validation of Baumannii Acinetobactin Utilization A Structure and Ligand Binding Site
- Genome-Wide Analysis of the bZIP Transcription Factors in Cucumber
- The imprint of codons on protein structure
- Two-intermediate model to characterize the structure of fast-folding proteins.
- Re-Evaluation of a Bacterial Antifreeze Protein as an Adhesin with Ice-Binding Activity
- Molecular Insights of p47phox Phosphorylation Dynamics in the Regulation of NADPH Oxidase Activation and Superoxide Production
- Validating a Coarse-Grained Potential Energy Function through Protein Loop Modelling
- Genome-Wide Investigation and Expression Analyses of WD40 Protein Family in the Model Plant Foxtail Millet (Setaria italica L.)
- Overview of computational vaccinology: vaccine development through information technology
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