Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells.

Keywords

Electrophoretic mobility shift assay, Reporter gene, Organic anion transporter 1, Chemistry, Oxidative stress

References

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• Enhanced Plasminogen Activator Inhibitor-1 Expression in Transgenic Mice with Hepatocyte-Specific Overexpression of Superoxide Dismutase or Glutathione PeroxidaseK. Franke, Katja Curth, Jacek Lenart — 2004
• Oral adsorbent AST-120 ameliorates tubular injury in chronic renal failure patients by reducing proteinuria and oxidative stress generation.Juan Gómez Calero — 2011
• The role of AST-120 and protein-bound uremic toxins in irritable bowel syndrome: a therapeutic perspectivePaula Mosińska, Martin Storr, Jakub Fichna — 2015
• Retention and toxicity of uremic solutes in chronic kidney disease.H. Mutsaers — 2014
• The importance of charged amino acids in the human Organic Anion Transporter 1Ahsan Rizwan — 2007
• Uremic Toxin Indoxyl Sulfate Inhibits Human Vascular Smooth Muscle Cell ProliferationAnaïs Mozar, Loı̈c Louvet, Patrice Morlière — 2011
• Association Between Indoxyl Sulfate and Skeletal Resistance in Hemodialysis PatientsShunsuke Goto, Hideki Fujii, Yasuhiro Hamada — 2010
• Improving removal of protein-bound retention solutes.Bert Bammens, Pieter Evenepoel — 2005
• Levels of indoxyl sulfate are associated with severity of coronary atherosclerosis.Chia‐Chang Hsu, Yung‐Chuan Lu, Cheng‐An Chiu — 2013
• EFFECT OF DEXAMETHASONE TREATMENT ON PAI-1 PRODUCTION BY HUMAN LUNG FIBROBLASTSKimiko Takahashi, Katsuyuki Kobayashi, Masako Mitsui — 2008
• Induction of PAI‐1 expression by tumor necrosis factor α in endothelial cells is mediated by its responsive element located in the 4G/5G siteMaria Świątkowska, Janusz Szemraj, Czesław S. Cierniewski — 2005
• Chronic Kidney Disease and Fibrosis: The Role of Uremic Retention SolutesHenricus A. M. Mutsaers, Elisabeth G. D. Stribos, Griet Glorieux — 2015
• Indoxyl sulfate exacerbates low bone turnover induced by parathyroidectomy in young adult rats.Junya Hirata, Kazuya Hirai, Hirobumi Asai — 2015
• PROGRESS IN UREMIC TOXIN RESEARCH: Protein‐Bound Toxins—Update 2009Noémie Jourde‐Chiche, Laetitia Dou, Claire Cérini — 2009
• Treatment With Pravastatin Attenuates Oxidative Stress and Protects Osteoblast Cell Viability From Indoxyl SulfateYoshiko Iwasaki, Hideyuki Yamato, Masafumi Fukagawa — 2011
• New Insight Into the Redox Properties of Uremic Solute Indoxyl Sulfate as a Pro‐ and Anti‐OxidantYohei Miyamoto, Hiroshi Watanabe, Masaki Otagiri — 2011
• Acarbose treatment lowers generation and serum concentrations of the protein-bound solute p-cresol: a pilot study.P. Evenepoel, Bert Bammens, Kristin Verbeke — 2006
• Indoxyl sulfate induces skeletal resistance to parathyroid hormone in cultured osteoblastic cells.Tomoko Nii‐Kono, Yuzuru Iwasaki, M. Uchida — 2007
• Update on the pharmacokinetics and redox properties of protein-bound uremic toxins.Hiroshi Watanabe, Yohei Miyamoto, Masaki Otagiri — 2011
• Organic Anion Transporters of the SLC22 Family: Biopharmaceutical, Physiological, and Pathological RolesAhsan Rizwan, Gerhard Burckhardt — 2007

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