What determines whether mammalian ribosomes resume scanning after translation of a short upstream open reading frame?

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Summary

Reinitiation in vitro suggests that resumption of scanning may depend on the interaction between eIF4F (or the eIF 4G central domain) and the ribosome being maintained while the Ribosome translates the sORF.

Type
article
Published
2004-01-01
Cited by
180
References
44
Access
Open access

Keywords

Biology, EIF4G, Upstream open reading frame, Open reading frame, Start codon

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