TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death
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Summary
The results suggest that the currently established role of the PARP pathway in TNF-induced necroptosis needs to be revised, with consequences for the design of future therapeutic strategies.
- Type
- article
- Published
- 2013-06-13
- Cited by
- 167
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W1976805974
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8614379
Keywords
Necroptosis, Poly ADP ribose polymerase, Programmed cell death, Tumor necrosis factor alpha, Biology
References
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- Necroptosis: the release of damage-associated molecular patterns and its physiological relevance.
- Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury.
- Poly(ADP-ribose) Polymerase-1 Signaling to Mitochondria in Necrotic Cell Death Requires RIP1/TRAF2-mediated JNK1 Activation*
- Phosphorylation-Driven Assembly of RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation
- The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets
- Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles.
- Oxidative stress initiates DNA damager MNNG-induced poly(ADP-ribose)polymerase-1-dependent parthanatos cell death.
- Hyperactivation of PARP Triggers Nonhomologous End-Joining in Repair-Deficient Mouse Fibroblasts
- Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways
- BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation
- Activation of an alternative death receptor-induced signaling pathway in human hepatocytes under caspase arrest.
- Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy
- The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest
- Poly ADP-ribose polymerase-1 and health
Cited by
- Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy
- Molecular and functional characterization of the signaling pathways that mediate TNF- and TRAIL-induced programmed necrosis.
- The serine threonine kinase RIP3: lost and found
- Assessment of Unique and Combined Functions of Poly(ADP-Ribose) Polymerases by Using RNA Interference
- The Impact of Regulated Cell Death Pathways on Alloimmune Responses and Graft Injury
- Combinative effects of β-Lapachone and APO866 on pancreatic cancer cell death through reactive oxygen species production and PARP-1 activation.
- Poly(ADP-ribosylation) and neurodegenerative disorders.
- Contribution of enhanced intrinsic apoptosis to renal ischemia reperfusion injury in the absence of RIPK3 and Caspase-8 dependent regulated cell death
- Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics
- Adalimumab Reduces Photoreceptor Cell Death in A Mouse Model of Retinal Degeneration
- Roles of NAD+, PARP-1, and Sirtuins in Cell Death, Ischemic Brain Injury, and Synchrotron Radiation X-Ray-Induced Tissue Injury
- Paraptosis triggers mitochondrial pathway-mediated apoptosis in Alzheimer’s disease
- Curcumin induces p53-independent necrosis in H1299 cells via a mitochondria-associated pathway.
- Wnt/β-Catenin signaling reduces Bacillus Calmette-Guerin-induced macrophage necrosis through a ROS -mediated PARP/AIF-dependent pathway
- Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury.
- Poly(ADP-ribose): a signaling molecule in different paradigms of cell death.
- Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
- E2F1-regulated miR-30b suppresses Cyclophilin D and protects heart from ischemia/reperfusion injury and necrotic cell death
- CXC Chemokine Ligand 12 Protects Pancreatic β-Cells from Necrosis through Akt Kinase-Mediated Modulation of Poly(ADP-ribose) Polymerase-1 Activity
- Chemical regulation of signaling pathways to programmed necrosis
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