A Dominant-negative Clathrin Mutant Differentially Affects Trafficking of Molecules with Distinct Sorting Motifs in the Class II Major Histocompatibility Complex (MHC) Pathway
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Summary
Differential packaging in CCVs in the TGN, mediated by tyrosine- and dileucine-based sorting signals, could be a mechanism for functional segregation of DM from DR–I chain until their intended rendezvous in late endocytic compartments.
- Type
- article
- Published
- 1998-03-09
- Cited by
- 138
- References
- 74
- Access
- Open access
- OpenAlex
- https://openalex.org/W1976483253
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14868439
Keywords
Clathrin, Endocytic cycle, Cell biology, Internalization, Biology
References
- In vitro binding of clathrin adaptors to sorting signals correlates with endocytosis and basolateral sorting.
- DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide.
- Stable surface expression of invariant chain prevents peptide presentation by HLA‐DR.
- Bovine brain clathrin light chains impede heavy chain assembly in vitro.
- Invariant chain prevents the HLA-DR-restricted presentation of a cytosolic peptide.
- β3A-adaptin, a Subunit of the Adaptor-like Complex AP-3*
- Mutations in human dynamin block an intermediate stage in coated vesicle formation
- Hyperinducible human metallothionein promoter with a low level basal activity.
- Living with clathrin: its role in intracellular membrane traffic.
- A new human HLA class II-related locus, DM
- Expression of Major Histocompatibility Complex Class II Molecules in HeLa Cells Promotes the Recruitment of AP-1 Golgi-specific Assembly Proteins on Golgi Membranes*
- Protein sorting by tyrosine-based signals: adapting to the Ys and wherefores.
- Interaction of tyrosine-based sorting signals with clathrin-associated proteins.
- Structural Determinants of Interaction of Tyrosine-based Sorting Signals with the Adaptor Medium Chains*
- A novel class of clathrin-coated vesicles budding from endosomes
- The biogenesis of the MHC class II compartment in human I-cell disease B lymphoblasts
- Enhanced Dissociation of HLA-DR-Bound Peptides in the Presence of HLA-DM
- Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization.
- Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells
- Clathrin: its role in receptor-mediated vesicular transport and specialized functions in neurons.
Cited by
- Intracellular transport of MHC class II and associated invariant chain in antigen presenting cells from AP-3-deficient mocha mice.
- Role of dynamin and clathrin in the cellular trafficking of flotillins
- Regulation of Self-Incompatibility by Endocytic Trafficking
- Mutations in PI(3,5)P2 Signaling and Neurodegeneration in Mouse and Human.
- CHARACTERISATION OF THE AP-3 ADAPTOR- LIKE COMPLEX
- Revisiting the Endocytosis of the M2 Muscarinic Acetylcholine Receptor
- Cutting Edge: Editing of Recycling Class II:Peptide Complexes by HLA-DM1
- Cutting edge: SIV Nef protein utilizes both leucine- and tyrosine-based protein sorting pathways for down-regulation of CD4.
- Osmotic Stress Modulates the Balance between Exocytosis and Clathrin-Mediated Endocytosis in Arabidopsis thaliana.
- Role of clathrin in the regulated secretory pathway of pancreatic beta-cells.
- Clathrin in gastric acid secretory (parietal) cells: biochemical characterization and subcellular localization.
- Exosome: from internal vesicle of the multivesicular body to intercellular signaling device.
- Internalization of the M2 muscarinic acetylcholine receptor proceeds through an atypical pathway in HEK293 cells that is independent of clathrin and caveolae.
- Expression of auxilin or AP180 inhibits endocytosis by mislocalizing clathrin: evidence for formation of nascent pits containing AP1 or AP2 but not clathrin.
- Association of Major Histocompatibility Complex II with Cholesterol- and Sphingolipid-rich Membranes Precedes Peptide Loading*
- Functional HLA‐DM on the surface of B cells and immature dendritic cells
- Protease-activated Receptor-1 Down-regulation
- Multiple internalization motifs differentially used by prolactin receptor isoforms mediate similar endocytic pathways.
- Endosomes: multipurpose designs for integrating housekeeping and specialized tasks
- Pitstop 2 Is a Potent Inhibitor of Clathrin-Independent Endocytosis
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