A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins.
Explore this paper's citation graph
Summary
The RKK, RK, and MAPKAP kinase-2 constitute a new stress-activated signal transduction pathway in vertebrates that is distinct from the classical MAPK cascade.
- Type
- article
- Published
- 1994-09-23
- Cited by
- 1,769
- References
- 61
- OpenAlex
- https://openalex.org/W1976462601
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19895515
Keywords
Biology, Mitogen-activated protein kinase kinase, Cell biology, MAP2K7, MAP kinase kinase kinase
References
- Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
- Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF.
- pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine.
- Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases.
- Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27.
- Transient activation of a distinct serine protein kinase is responsible for 27-kDa heat shock protein phosphorylation in mitogen-stimulated and heat-shocked cells.
- Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II.
- Interleukin 1 and tumour necrosis factor increase phosphorylation of the small heat shock protein
- Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock. HSP27 stabilization of the microfilament organization.
- Stress‐ and mitogen‐induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance.
- Induction of four proteins in chick embryo cells by sodium arsenite.
- MAPKAP kinase‐2; a novel protein kinase activated by mitogen‐activated protein kinase.
- Tumor necrosis factor stimulates multiple serine/threonine protein kinases in Swiss 3T3 and L929 cells. Implication of casein kinase-2 and extracellular signal-regulated kinases in the tumor necrosis factor signal transduction pathway.
- The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2.
- pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity.
- Identification of the sites in MAP kinase kinase‐1 phosphorylated by p74raf‐1.
- Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle.
- Phorbol ester, calcium ionophore, or serum added to quiescent rat embryo fibroblast cells all result in the elevated phosphorylation of two 28,000-dalton mammalian stress proteins.
- Interleukin 1 and tumor necrosis factor stimulate two novel protein kinases that phosphorylate the heat shock protein hsp27 and beta-casein.
- Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts
Cited by
- La protéine de stress Hsp27 / HspB1, une cible de choix en thérapie anti-cancéreuse
- sHsp-phosphorylation: enzymes, signaling pathways and functional implications.
- Phosphorylation state of the RNA polymerase II C-terminal domain (CTD) in heat-shocked cells. Possible involvement of the stress-activated mitogen-activated protein (MAP) kinases.
- Heat shock proteins are differentially expressed in human gastrointestinal cancers.
- Role for p38 Mitogen-activated Protein Kinase in Platelet Aggregation Caused by Collagen or a Thromboxane Analogue (*)
- Interleukin 1 (IL1) and tumour necrosis factor (TNF) signal transduction.
- LSP1 Is the Major Substrate for Mitogen-activated Protein Kinase-activated Protein Kinase 2 in Human Neutrophils*
- Tumor Necrosis Factor α-Induced E-selectin Expression Is Activated by the Nuclear Factor-κB and c-JUN N-terminal Kinase/p38 Mitogen-activated Protein Kinase Pathways*
- Phosphorylation of Protein-tyrosine Phosphatase PTP-1B on Identical Sites Suggests Activation of a Common Signaling Pathway during Mitosis and Stress Response in Mammalian Cells*
- Distinct Regulation of Osmoprotective Genes in Yeast and Mammals
- A Role for the p38 Mitogen-activated Protein Kinase Pathway in Myocardial Cell Growth, Sarcomeric Organization, and Cardiac-specific Gene Expression
- Heat Shock Increases the Association of Binding Protein-1 with Initiation Factor 4E*
- Signal transduction through MAP kinase cascades.
- Opposing Effects of Jun Kinase and p38 Mitogen-Activated Protein Kinases on Cardiomyocyte Hypertrophy
- Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease.
- Protein phosphorylation in alveolar macrophages after stimulation with heavy metal-coated silica particles.
- Murine p38-δ Mitogen-activated Protein Kinase, a Developmentally Regulated Protein Kinase That Is Activated by Stress and Proinflammatory Cytokines*
- Stimulation of Elk1 Transcriptional Activity by Mitogen-activated Protein Kinases Is Negatively Regulated by Protein Phosphatase 2B (Calcineurin)*
- C-reactive Protein Inhibits Chemotactic Peptide-induced p38 Mitogen-activated Protein Kinase Activity and Human Neutrophil Movement*
- Involvement of mitogen-activated protein kinase homologues in the regulation of lipopolysaccharide-mediated induction of cyclo-oxygenase-2 but not nitric oxide synthase in RAW 264.7 macrophages.
Related papers
- A gene encoding a mitogen-activated protein kinase kinase kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, cold, and water stress in Arabidopsis thaliana.
- Role of MLK3 in the Regulation of Mitogen-Activated Protein Kinase Signaling Cascades
- Mechanical stress activates protein kinase cascade of phosphorylation in neonatal rat cardiac myocytes.
- Insulin inhibits glucocorticoid-stimulated L-type 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression by activation of the c-Jun N-terminal kinase pathway
- The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells.
- The FLT3 internal tandem duplication mutation prevents apoptosis in interleukin-3-deprived BaF3 cells due to protein kinase A and ribosomal S6 kinase 1-mediated BAD phosphorylation at serine 112.
- Insulin inhibits glucocorticoid-stimulated L-type 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression by activation of the c-Jun N-terminal kinase pathway.
- Functional divergence of the MAP kinase pathway ERK1 and ERK2 activate specific transcription factors
- Biochemical characterization of mitogen-activated protein (MAP) kinase activity in Toxoplasma gondii
- Involvement of protein kinase C during activation of the mitogen-activated protein kinase cascade by leukemia inhibitory factor. Evidence for participation of multiple signaling pathways.