Immunoreactive growth hormone receptor/binding protein is present on fibroblasts and in serum of Laron-type dwarfs.
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Summary
It is demonstrated that in cultured skin fibroblasts derived from four patients with Laron-type dwarfism the GH receptor gene is transcribed and the GH receptors protein is expressed on the cell surface.
- Type
- article
- Published
- 1994-02-01
- Cited by
- 5
- References
- 31
- OpenAlex
- https://openalex.org/W1976118900
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29392933
Keywords
Dwarfism, Growth hormone-binding protein, Endocrinology, Internal medicine, Receptor
References
- Evidence from the use of monoclonal antibody probes for structural heterogeneity of the growth hormone receptor.
- The human growth hormone receptor of cultured human lymphocytes. Structural characteristics and glycosylation properties.
- Regulation of rat growth hormone receptor gene expression.
- Radioimmunoassay for somatomedin C: comparison with radioreceptor assay in patients with growth-hormone disorders, hypothyroidism, and renal failure.
- Rat growth hormone (GH) but not prolactin (PRL) induces both GH and PRL receptors in female rat liver.
- Receptor-active growth hormone in Laron dwarfism.
- Demonstration and localization of growth hormone receptor in human skin and skin fibroblasts.
- A second, lower affinity growth hormone-binding protein in human plasma.
- Identification and tissue distribution of messenger RNA for the growth hormone receptor in the rabbit.
- Absence of the plasma growth hormone-binding protein in Laron-type dwarfism.
- Lack of hormone binding in COS-7 cells expressing a mutated growth hormone receptor found in Laron dwarfism.
- Laron dwarfism and mutations of the growth hormone-receptor gene.
- Recurrent nonsense mutations in the growth hormone receptor from patients with Laron dwarfism.
- Administration of growth hormone to patients with familial dwarfism with high plasma immunoreactive growth hormone: measurement of sulfation factor, metabolic and linear growth responses.
- Characterization of the growth hormone-binding protein of human serum using a panel of monoclonal antibodies.
- Radioreceptor and radioimmunoassay quantitation of human growth hormone in acromegalic serum: overestimation by immunoassay and systematic differences between antisera.
- EXPERIENCE WITH HUMAN GROWTH HORMONE IN GREAT BRITAIN: THE REPORT OF THE MRC WORKING PARTY
- Post-transcriptional regulation of glyceraldehyde-3-phosphate-dehydrogenase gene expression in rat tissues.
- Different effects of intermittent and continuous growth hormone (GH) administration on serum somatomedin-C/insulin-like growth factor I and liver GH receptors in hypophysectomized rats.
- United Kingdom multicentre clinical trial of somatrem.
Cited by
- Growth Hormone-Binding Proteins
- Growth hormone receptor abundance in tibial growth plates of uremic rats: GH/IGF-I treatment.
- Overnight growth hormone concentrations are usually normal in pubertal children with idiopathic short stature--a Clinical Research Center study.
- Human skin fibroblasts as a model of growth hormone (GH) action in GH receptor-positive Laron's syndrome.
- Growth hormone insensitivity.
- Human Skin Fibroblasts as a Model of Growth Hormone (GH) Action in GH Receptor-Positive Laron's Syndrome
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