Recognition of uridine diphosphate glucuronosyl transferases by LKM-3 antibodies in chronic hepatitis D.
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Summary
The UGT proteins are part of the phase II enzymes of drug metabolism and are the first such enzymes to be identified as human autoantigens.
- Type
- article
- Published
- 1994-08-27
- Cited by
- 115
- References
- 31
- OpenAlex
- https://openalex.org/W1976054841
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40104249
Keywords
Autoantibody, Antibody, Antigen, Uridine diphosphate, Hepatitis
References
- Autoantibodies in chronic delta virus infection recognize a common protein of 46 kD in rat forestomach basal cell layer and stellate thymic epithelial cells.
- A mutation in bilirubin uridine 5'-diphosphate-glucuronosyltransferase isoform 1 causing Crigler-Najjar syndrome type II.
- Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family.
- Cassette mutagenesis of a potential substrate recognition region of cytochrome P450 2C2.
- Organization of the rat UDP-glucuronosyltransferase, UDPGTr-2, gene and characterization of its promoter.
- Cloning and characterization of rabbit liver UDP-glucuronosyltransferase cDNAs. Developmental and inducible expression of 4-hydroxybiphenyl UGT2B13.
- Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase.
- A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.
- High resolution two-dimensional electrophoresis of proteins.
- Type II autoimmune hepatitis. What is the role of the hepatitis C virus?
- Expression of bovine 17 alpha-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS 1) cells.
- Anti-GOR and hepatitis C virus in autoimmune liver diseases.
- LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase.
- A comprehensive set of sequence analysis programs for the VAX
- Isolation, Sequence, and Developmental Expression of Rat UGT2B2: The Gene Encoding a Constitutive UDP Glucuronosyltransferase That Metabolizes Etiocholanolone and Androsterone
- Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1.
- Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II.
- Structure, sequence and expression of the hepatitis delta (δ) viral genome
- Identification of cytochrome P450IA2 as a human autoantigen.
- Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patient.
Cited by
- Characterization of autoantibodies against uridine‐diphosphate glucuronosyltransferase in patients with inflammatory liver diseases
- Natural course and treatment of hepatitis D virus infection.
- cDNA Cloning of the Mouse Bilirubin/Phenol Family of UDP-Glucuronosyltransferase (mUGTbr2-like)
- Autoantibodies and liver disease: uses and abuses.
- Effectors and regulators of cellular immune response in autoimmune liver disease
- Recent advances in autoimmune liver diseases.
- Hepatitis delta virus infection: open issues.
- Viral induction of autoimmunity: mechanisms and examples in hepatology
- Recent developments in autoimmune liver diseases
- Cytochrome P450 1A2 is a hepatic autoantigen in autoimmune polyglandular syndrome type 1.
- Heterogeneity of liver-kidney microsomal autoantibodies in chronic hepatitis C and D virus infection.
- Gene Replacement Therapy for Genetic Hepatocellular Jaundice
- Autoimmune hepatitis versus viral hepatitis C.
- A Major CYP2D6 Autoepitope in Autoimmune Hepatitis Type 2 and Chronic Hepatitis C is a Three-dimensional Structure Homologous to Other Cytochrome P450 Autoantigens
- Autoimmunity in liver diseases
- Current concepts in the diagnosis, pathogenesis, and treatment of autoimmune hepatitis.
- STRUCTURE AND FUNCTION OF URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASES
- A Review of Methods Available for the Identification of Both Organ-Specific and Non-Organ-Specific Autoantibodies
- Cytochrome P450 enzymes and UDP-Glucuronosyltransferases as hepatocellular autoantigens
- Autoantibodies and defined target autoantigens in autoimmune hepatitis: an overview.
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