Glutathione peroxidase activity in selenium-deficient rat liver.
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Summary
Two peaks of glutathione peroxidase activity were present in the Sephadex G-150 gel filtration chromatogram of rat liver supernatant when 1.5 mM cumene hydroperoxide was used as substrate, and the second peak represents a second glutathienase activity which catalyzes the destruction of organic hydroperoxides but has little activity toward H 2 O 2 and which persists in severe selenium deficiency.
- Type
- article
- Published
- 1976-08-23
- Cited by
- 3,395
- References
- 13
- OpenAlex
- https://openalex.org/W1975980695
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45675220
Keywords
Cumene hydroperoxide, Sephadex, Chemistry, Selenium, Peroxidase
References
- Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat.
- Purification and properties of human erythrocyte glutathione peroxidase.
- Hemoglobin catabolism. I. Glutathione peroxidase, an erythrocyte enzyme which protects hemoglobin from oxidative breakdown.
- Protein measurement with the Folin phenol reagent.
- Glutathione peroxidase: A selenoenzyme
- Some effects of selenium deficiency on the hepatic microsomal cytochrome P-450 system in the rat.
- An intracellular GSH-peroxidase with a lipid peroxide substrate.
- Selenium as a component of glutathione periodase isolated from ovine erythrocytes.
- The purification and properties of glutathione peroxidase of erythrocytes.
- Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.
- Response of glutathione peroxidase to dietary selenium in rats.
- Untersuchungen über die Glutathion:H 2 O 2 -Oxydoreduktase (Glutathion-Peroxydase)
Cited by
- Glutathione peroxidase activities from rat liver.
- Plasmodium falciparum induced perturbations of the erythrocyte antioxidant system.
- Glutathione-related enzyme activities and lipoperoxide levels in human internal mammary artery and ascending aorta. Relations with serum lipids.
- The Role of Selenium Nutrition in the Development of Neonatal Rat Lung
- Effect of excess dietary zinc on pancreatic exocrine function in the chick.
- A novel interaction of diethyldithiocarbamate with the glutathione/glutathione peroxidase system.
- Effects of dietary selenium and vitamin E on boar performance and tissue responses, semen quality, and subsequent fertilization rates in mature gilts.
- Effect of chronic ethanol treatment under partial catalase inhibition on the activity of enzymes related to peroxide metabolism in rat liver and heart.
- Production of selenium deficiency in the rat.
- The role of hydroperoxides as calcium release agents in rat brain mitochondria.
- Selenium- and non-selenium-dependent glutathione peroxidases in mouse liver.
- The metabolic fate of mitochondrial hydrogen peroxide.
- Macrophage oxygen-dependent antimicrobial activity. IV. Role of endogenous scavengers of oxygen intermediates
- The role of the glutathione-dependent system in tumor sensitivity to cisplatin: a study of human tumor xenografts.
- The separation and identification of glutathione S-transferase subunits from Orthosia gothica.
- Trace Element Status and Free Radical Defense in Elderly Rhesus Macaques (Macaca mulatta) with Macular Drusen
- Mitochondrial Dysfunctions During Aging: Vitamin E Deficiency or Caloric Restriction–Two Different Ways of Modulating Stress
- In vitro modulation of antioxidant enzyme levels in normal hamster kidney and estrogen-induced hamster kidney tumor.
- Modulation of cellular antioxidant defense activities by sodium arsenite in human fibroblasts
- Lipid peroxidation and activities of antioxidant enzymes in iron deficiency and effect of carcinogen feeding.
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