KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance
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Summary
There is a clear prognostic and therapeutic rationale for detection of KIT D816V and JAK2 V617F in the diagnostic work up of eosinophilia.
- Type
- article
- Published
- 2015-09-01
- Cited by
- 55
- References
- 28
- Access
- Open access
- OpenAlex
- https://openalex.org/W1975966893
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25115394
Keywords
Systemic mastocytosis, Eosinophilia, Medicine, Hypereosinophilia, Internal medicine
References
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- The 2008 World Health Organization classification system for myeloproliferative neoplasms
- Response of ETV6-FLT3-positive myeloid/lymphoid neoplasm with eosinophilia to inhibitors of FMS-like tyrosine kinase 3.
- KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities.
- Minimal residual disease after allogeneic bone marrow transplantation for chronic myeloid leukaemia in first chronic phase: correlations with acute graft‐versus‐host disease and relapse
- JAK/STAT-dependent gene regulation by cytokines.
- Comprehensive mutational profiling in advanced systemic mastocytosis.
- A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome.
- The t(8;17)(p11;q23) in the 8p11 myeloproliferative syndrome fuses MYO18A to FGFR1
- Eosinophilia: secondary, clonal and idiopathic
- Identification of a MYO18A‐PDGFRB fusion gene in an eosinophilia‐associated atypical myeloproliferative neoplasm with a t(5;17)(q33‐34;q11.2)
- Screening for JAK2 V617F point mutation in patients with hypereosinophilic syndrome-in response to 'Hypereosinophilic syndrome: another face of janus?' by Dahabreh et al. published in Leukemia Research, in press.
- Limited duration of complete remission on ruxolitinib in myeloid neoplasms with PCM1-JAK2 and BCR-JAK2 fusion genes
- Management of Hypereosinophilic Syndrome: A Prospective Study in the Era of Molecular Genetics
- Long-term follow-up of treatment with imatinib in eosinophilia-associated myeloid/lymphoid neoplasms with PDGFR rearrangements in blast phase
- Polycythemia vera and essential thrombocythemia: 2012 update on diagnosis, risk stratification, and management
- The KIT D816V expressed allele burden for diagnosis and disease monitoring of systemic mastocytosis
- The molecular anatomy of the FIP1L1-PDGFRA fusion gene
Cited by
- Targeted next-generation sequencing identifies a subset of idiopathic hypereosinophilic syndrome with features similar to chronic eosinophilic leukemia, not otherwise specified
- Blood and Bone Marrow Evaluation for Eosinophilia.
- Myeloid neoplasms with eosinophilia.
- Guideline for the investigation and management of eosinophilia
- Bone marrow morphology is a strong discriminator between chronic eosinophilic leukemia, not otherwise specified and reactive idiopathic hypereosinophilic syndrome
- Tyrosine Kinase Inhibitors in the Treatment of Eosinophilic Neoplasms and Systemic Mastocytosis.
- Ruxolitinib found to cause eyelash growth: a case report
- Cytogenetically cryptic ZMYM2-FLT3 and DIAPH1-PDGFRB gene fusions in myeloid neoplasms with eosinophilia
- Eosinophils from Physiology to Disease: A Comprehensive Review
- Human eosinophils and mast cells: birds of a feather flock together
- Routine Screening for KIT M541L Is Not Warranted in the Diagnostic Work-Up of Patients with Hypereosinophilia
- The Diagnostic Work-Up of Hypereosinophilia
- A multimodality work‐up of patients with Hypereosinophilia
- The Spectrum of Hypereosinophilia and Associated Clonal Disorders – A Real-World Data Based on Combined Retrospective and Prospective Analysis from a Tropical Setting
- Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia
- Evidence of clonality in cases of hypereosinophilia of undetermined significance
- World Health Organization‐defined eosinophilic disorders: 2017 update on diagnosis, risk stratification, and management
- Severe asthma with blood hypereosinophilia associated with JAK2 V617F mutation: a case series
- Skin-limited idiopathic hypereosinophilic syndrome presenting with retiform purpura
- World Health Organization‐defined eosinophilic disorders: 2019 update on diagnosis, risk stratification, and management
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