IFN-gamma regulates the expression of B7-H1 in dermal fibroblast cells.
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Summary
The data provides the first evidence to demonstrate that dermal fibroblast express the B7-H1 mRNA in the process of skin inflammation, and suggests the involvement of NF-kappaB and MAPK and PI3K, that may play some important roles in inflammation process in human skin diseases.
- Type
- article
- Published
- 2005-11-01
- Cited by
- 125
- References
- 30
- OpenAlex
- https://openalex.org/W1975867402
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19846940
Keywords
Fibroblast, Molecular biology, Dermal fibroblast, Transcription factor, Biology
References
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- House dust mite allergen exerts no direct proinflammatory effects on human keratinocytes.
- Integrin signalling and tyrosine phosphorylation: just the FAKs?
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- CC and CXC chemokines are differentially expressed in erythema multiforme in vivo.
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- Regulation of Interleukin-1α Expression by Integrins and Epidermal Growth Factor Receptor in Keratinocytes from a Mouse Model of Inflammatory Skin Disease*
- Human muscle cells express a B7‐related molecule, B7‐H1, with strong negative immune regulatory potential: a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies
Cited by
- Targeting JAK kinase in solid tumors: emerging opportunities and challenges
- A novel regulation of PD-1 ligands on mesenchymal stromal cells through MMP-mediated proteolytic cleavage
- TLR4 Activation Enhances the PD-L1-Mediated Tolerogenic Capacity of Colonic CD90+ Stromal Cells,
- Immunopathogenesis of Myocarditis: The Interplay Between Cardiac Fibroblast Cells, Dendritic Cells, Macrophages and CD4+T Cells
- The immunoinhibitory B7-H1 molecule as a potential target in cancer: killing many birds with one stone.
- Stimulation of B7-H1 in Hepatocarcinoma Cells by Hepatitis B virus X Antigen
- Anti-PD-1 therapy in melanoma.
- Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
- TLR3 triggering regulates PD-L1 (CD274) expression in human neuroblastoma cells.
- 12-O-tetradecanoyl phorbol 13-acetate induces the expression of B7-DC, -H1, -H2, and -H3 in K562 cells.
- Clinical significance of B7-H1（PD-L1）expression in human acute leukemia
- ERK/p38 MAP‐kinases and PI3K are involved in the differential regulation of B7‐H1 expression in DC subsets
- Immunological in vivo effects of B7-H1 deficiency.
- Induced B7-H1 expression on human renal tubular epithelial cells by the sublytic terminal complement complex C5b-9.
- Intrinsic modulation of lymphocyte function by stromal cell network: advance in therapeutic targeting of cancer.
- NF-κB Plays a Key Role in Inducing CD274 Expression in Human Monocytes after Lipopolysaccharide Treatment
- PD-1 ligand expression by human colonic myofibroblasts/fibroblasts regulates CD4+ T cell activity
- Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma.
- Interferon regulatory factor‐1 is prerequisite to the constitutive expression and IFN‐γ‐induced upregulation of B7‐H1 (CD274)
- In acute myeloid leukemia, B7-H1 (PD-L1) protection of blasts from cytotoxic T cells is induced by TLR ligands and interferon-gamma and can be reversed using MEK inhibitors
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