Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy.
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Summary
The role of inflammation in the pathogenesis of CF lung disease is examined, the results of past clinical trials are summarized, and promising new anti-inflammatory options are explored.
- Type
- review
- Published
- 2015-07-01
- Cited by
- 452
- References
- 157
- Access
- Open access
- OpenAlex
- https://openalex.org/W1975572445
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9916783
Keywords
Cystic fibrosis, Medicine, Cystic fibrosis transmembrane conductance regulator, Inflammation, Immunology
References
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- Inhaled versus systemic antibiotics and airway inflammation in children with cystic fibrosis and Pseudomonas
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- Degradation Kinetics of BMP 777, an Elastase Inhibitor
- ANTI-PCRV ANTIBODY IN CYSTIC FIBROSIS: A NOVEL APPROACH TARGETING PSEUDOMONAS AERUGINOSA AIRWAY INFECTION
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- Reduced caveolin-1 promotes hyper-inflammation due to abnormal heme oxygenase-1 localizationin LPS challenged macrophages with dysfunctional CFTR
- Galectin-9 Signaling through TIM-3 Is Involved in Neutrophil-Mediated Gram-Negative Bacterial Killing: An Effect Abrogated within the Cystic Fibrosis Lung
- A Novel Proteolytic Cascade Generates an Extracellular Matrix-Derived Chemoattractant in Chronic Neutrophilic Inflammation12
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- High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis.
- Risk of persistent growth impairment after alternate-day prednisone treatment in children with cystic fibrosis.
- A randomized double blind, placebo controlled phase 2 trial of BIIL 284 BS (an LTB4 receptor antagonist) for the treatment of lung disease in children and adults with cystic fibrosis.
- Long-term treatment with oral N-acetylcysteine: affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled trial.
- SerpinB1 in cystic fibrosis airway fluids: quantity, molecular form and mechanism of elastase inhibition
Cited by
- Update on the spider and the fly: An extended commentary on “Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-Oxidase activation”
- Innate Immunity in Cystic Fibrosis: Novel Pieces of the Puzzle
- X-Box-Binding Protein 1 and Innate Immune Responses of Human Cystic Fibrosis Alveolar Macrophages.
- Hallmarks of Therapeutic Management of the Cystic Fibrosis Functional Landscape
- Therapeutic Effects of α1-Antitrypsin on Psedumonas aeruginosa Infection in ENaC Transgenic Mice
- Respiratory tract exacerbations revisited: Ventilation, inflammation, perfusion, and structure (VIPS) monitoring to redefine treatment
- Macrophage and Innate Lymphoid Cell Interplay in the Genesis of Fibrosis
- Mutations of Cystic Fibrosis Transmembrane Conductance Regulator Gene Cause a Monocyte-Selective Adhesion Deficiency.
- Cystic fibrosis -- From basic science to clinical benefit: A review series.
- Reversible airway obstruction in cystic fibrosis: Common, but not associated with characteristics of asthma.
- Changes in airway inflammation during pulmonary exacerbations in patients with cystic fibrosis and primary ciliary dyskinesia
- Ultrasound and magnetic resonance imaging assessment of joint disease in symptomatic patients with cystic fibrosis arthropathy.
- Innate and Adaptive Immunity in Cystic Fibrosis.
- Chitosan as a non-viral co-transfection system in a cystic fibrosis cell line.
- The role of glutathione reductase and related enzymes on cellular redox homoeostasis network.
- Update on host-pathogen interactions in cystic fibrosis lung disease
- New frontiers for anti-biofilm drug development.
- Dysregulated Chemokine Signaling in Cystic Fibrosis Lung Disease: A Potential Therapeutic Target
- Modulating innate and adaptative immunity by (R)-roscovitine: potential therapeutic opportunity in cystic fibrosis
- Progress in therapies for cystic fibrosis.
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