The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies.
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Summary
It is concluded that effects on learning and memory performance which are observed after higher doses of scopolamine are mediated by primary effects on attention and sensory/stimulus discrimination, and non-specific effects on behavior (e.g., locomotor activity, anxiety).
- Type
- review
- Published
- 2010-07-01
- Cited by
- 688
- References
- 368
- OpenAlex
- https://openalex.org/W1975286611
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26180027
Keywords
Psychology, Mnemonic, Cognition, Neuroscience, Scopolamine
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Cited by
- The M₁/M₄ preferring agonist xanomeline reverses amphetamine-, MK801- and scopolamine-induced abnormalities of latent inhibition: putative efficacy against positive, negative and cognitive symptoms in schizophrenia.
- Basal forebrain activation controls contrast sensitivity in primary visual cortex
- Neuroprotective action of N-acetyl serotonin in oxidative stress-induced apoptosis through the activation of both TrkB/CREB/BDNF pathway and Akt/Nrf2/Antioxidant enzyme in neuronal cells
- Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model
- Understanding Central Nervous System Effects of Deliriant Hallucinogenic Drugs through Experimental Animal Models.
- Muscarinic M1 receptor modulation of cognition using a translational approach : relevance for dementia and schizophrenia
- Can PDE inhibition improve cognition? : Translational insights
- The muscarinic system, cognition and schizophrenia.
- Validation and scopolamine-reversal of latent learning in the water maze utilizing a revised direct platform placement procedure.
- AVALIAÇÃO DOS EFEITOS DE COMPOSTOS POLIFENÓLICOS EM PARÂMETROS BIOQUÍMICOS E NO TRATAMENTO DE DÉFICITS COGNITIVOS ASSOCIADOS À ADMINISTRAÇÃO DE ESCOPOLAMINA EM PEIXE ZEBRA ( Danio rerio )
- Antiamnesic and Antioxidants Effects of Ferulago angulata Essential Oil Against Scopolamine-Induced Memory Impairment in Laboratory Rats
- α7 nicotinic acetylcholine receptors and memory processes: mechanistic and behavioral studies
- Prophylactic Effect of Hypericum Perforatum L. Extract in ScopolamineRat Model of Cognitive Dysfunction
- Cholinergic and serotonergic modulations differentially affect large-scale functional networks in the mouse brain
- Behavioral effects of deep brain stimulation of different areas of the Papez circuit on memory- and anxiety-related functions.
- The short- and long-term effects of orally administered high-dose reduced graphene oxide nanosheets on mouse behaviors.
- Pharmacological Assessment of Novel Phenylacetamide as a Sigma 1 Receptor Ligand
- Effects of Altering Motivation in Pigeons Performing a Titrating-Delayed-Matching-To-Sample Task
- Efficient biosynthesis of rare natural product scopolamine using E. coli cells expressing a S14P/K97A mutant of hyoscyamine 6β-hydroxylase AaH6H.
- Pharmakologische und nicht-pharmakologische Effekte auf die Kognition
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