Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense.
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Summary
It is found that IL-6 and IFN-alpha levels in nasal lavage fluids peaked early (day 2) and correlated directly with viral titers, temperature, mucus production, and symptom scores, which implicate IL- 6 and IFn-alpha as key factors both in symptom formation and host defense in influenza.
- Type
- article
- Published
- 1998-02-01
- Cited by
- 682
- References
- 31
- Access
- Open access
- OpenAlex
- https://openalex.org/W1974668319
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1737583
Keywords
Immunology, Cytokine, Viral shedding, Respiratory system, Mucus
References
- Role of macrophage cytokines in influenza A virus infections.
- Tumor necrosis factor as a mediator of inflammation in influenza A viral pneumonia.
- Influenza A virus infection of macrophages. Enhanced tumor necrosis factor-alpha (TNF-alpha) gene expression and lipopolysaccharide-triggered TNF-alpha release.
- An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections.
- A kinetic study of immune mediators in the lungs of mice infected with influenza A virus.
- Presence of interferon in acute- and convalescent-phase sera of humans with influenza or influenza-like illness of undetermined etiology.
- Estimation of nasal epithelial lining fluid using urea as a marker.
- Expression of IL-6, IL-8, and RANTES on human bronchial epithelial cells, NCI-H292, induced by influenza virus A.
- Treatment of chronic viral hepatitis.
- Influenza virus A infection induces interleukin-8 gene expression in human airway epithelial cells.
- Production of interleukin 1 and tumour necrosis factor activities in bronchoalveolar washings following infection of mice by influenza virus.
- Stimulation of tumor necrosis factor secretion by purified influenza virus neuraminidase.
- Nasal cytokine production in viral acute upper respiratory infection of childhood.
- Infection of macrophages by influenza A virus: characteristics of tumour necrosis factor-alpha (TNF alpha) gene expression.
- Characterization of Early Cytokine Responses and an Interleukin (IL)-6–dependent Pathway of Endogenous Glucocorticoid Induction during Murine Cytomegalovirus Infection
- Rhinovirus stimulation of interleukin-6 in vivo and in vitro. Evidence for nuclear factor kappa B-dependent transcriptional activation.
- Interleukin-6: an overview.
- Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells
- Cytokines and the acute phase response to influenza virus in mice.
- Phase I trial of subcutaneous interleukin-6 in patients with advanced malignancies.
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- 2009 update in prevention, evaluation, and outpatient treatment of influenza
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- The effects of neuraminidase inhibitors on the release of oseltamivir‐sensitive and oseltamivir‐resistant influenza viruses from primary cultures of human tracheal epithelium
- Integrative analysis of differentially expressed microRNAs of pulmonary alveolar macrophages from piglets during H1N1 swine influenza A virus infection
- Host‐pathogen kinetics during influenza infection and coinfection: insights from predictive modeling
- Viral characteristics of influenza.
- Pathophysiology of Clinical Symptoms in Acute Viral Respiratory Tract Infections
- Comparison of the CD4+ T cell and antibody responses to different Influenza vaccination regimens and to infection in naive and pre-exposed mice
- The Geriatric Cytokine Response to Trauma: Time To Consider a New Threshold
- The role of cytokine responses during influenza virus pathogenesis and potential therapeutic options.
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- Neurologic aspects of influenza viruses
- Molecular pathogenesis of influenza in swine and engineering of novel recombinant influenza viruses
- Strategy to improve swine influenza virus (SIV) vaccination
- Nonlinear Hierarchical Models for Longitudinal Experimental Infection Studies
- Pandemic Swine-Origin H1N1 Influenza Virus Replicates to Higher Levels and Induces More Fever and Acute Inflammatory Cytokines in Cynomolgus versus Rhesus Monkeys and Can Replicate in Common Marmosets
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