A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae
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Summary
A high-density transposon mutagenesis strategy was applied to the Haemophilus influenzae genome to identify genes required for growth or viability, and a genome-scale phenotypic analysis identifies potential roles for a large set of genes of unknown function.
- Type
- article
- Published
- 2002-01-22
- Cited by
- 377
- References
- 30
- Access
- Open access
- OpenAlex
- https://openalex.org/W1974299093
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6565308
Keywords
Biology, Haemophilus influenzae, Genome, Gene, Genetics
References
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- Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.
- Systematic function analysis of Bacillus subtilis genes.
- Functional genomics of Escherichia coli in Japan.
- In vivo transposition of mariner-based elements in enteric bacteria and mycobacteria.
- Systematic identification of essential genes by in vitro mariner mutagenesis.
- Frequency and distribution of DNA uptake signal sequences in the Haemophilus influenzae Rd genome.
- Systematic Identification of Selective Essential Genes in Helicobacter pylori by Genome Prioritization and Allelic Replacement Mutagenesis
- Identification of the Key Protein for Zinc Uptake in Hemophilus influenzae *
- Identification of Critical Staphylococcal Genes Using Conditional Phenotypes Generated by Antisense RNA
- A genome-based approach for the identification of essential bacterial genes
- An eleven-base-pair sequence determines the specificity of DNA uptake in Haemophilus transformation.
- Role of nontypeable Haemophilus influenzae in pediatric respiratory tract infections.
- Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step.
- Charged tmRNA but not tmRNA‐mediated proteolysis is essential for Neisseria gonorrhoeae viability
- Binding and cross‐linking of tmRNA to ribosomal protein S1, on and off the Escherichia coli ribosome
- Community-acquired pneumonia in adults: guidelines for management. The Infectious Diseases Society of America.
Cited by
- Discovering essential domains in essential genes.
- Highly sensitive target-based whole-cell antibacterial discovery strategy by antisense RNA silencing.
- Identification of Essential Genes in the Human Fungal Pathogen Aspergillus fumigatus by Transposon Mutagenesis
- trans-translation-mediated tight regulation of the expression of the alternative ribosome-rescue factor ArfA in Escherichia coli.
- Microarray transposon tracking for the mapping of conditionally essential genes in Campylobacter jejuni.
- Advances and perspectives in computational prediction of microbial gene essentiality.
- Identification of Streptococcus mitis321A vaccine antigens based on reverse vaccinology
- Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE
- Chemical genetics: an evolving toolbox for target identification and lead optimization.
- Genomics of host-pathogen interactions.
- Structural and functional studies of enzymes in nucleotide metabolism
- A subsystems-based approach to the identification of drug targets in bacterial pathogens.
- High-throughput insertion tracking by deep sequencing for the analysis of bacterial pathogens.
- Gene essentiality analysis based on DEG, a database of essential genes.
- Computational Prediction of Protein-Protein Interactions on the Proteomic Scale Using Bayesian Ensemble of Multiple Feature Databases
- Identification of inhibitors of bacterial RNA polymerase.
- Modulators of Symbiotic Outcome in Sinorhizobium meliloti
- Novel Genetic Techniques and Approaches in the Microbial Genomics Era
- Cell-Like Entities: On the Boundary Between Non-Living and Living
- Role of the two ClpP protease subunits in Mycobacterium tuberculosis
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