A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus.
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Summary
It is demonstrated that --1021C-->T is a major genetic marker for plasma-D beta H activity and provide new tools for investigation of the role of both D beta H and the DBH gene in human disease.
- Type
- article
- Published
- 2001-02-01
- Cited by
- 283
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W1974135788
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1769150
Keywords
Quantitative trait locus, Locus (genetics), Biology, Allele, Genetics
References
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- Human serum dopamine beta-hydroxylase: correlation of enzymatic activity with immunoreactive protein in genetically defined samples.
- An Analysis of Transformations
- Linkage of a gene regulating dopamine-beta-hydroxylase activity and the ABO blood group locus.
- Neuron-specific expression of the human dopamine beta-hydroxylase gene requires both the cAMP-response element and a silencer region.
- Segregation and linkage studies of plasma dopamine-beta-hydroxylase (DBH), erythrocyte catechol-O-methyltransferase (COMT), and platelet monoamine oxidase (MAO): possible linkage between the ABO locus and a gene controlling DBH activity.
- Searching for genetic determinants in the new millennium
- Cell-specific expression from the human dopamine beta-hydroxylase promoter in transgenic mice is controlled via a combination of positive and negative regulatory elements
- The primary structure of human dopamine‐beta‐hydroxylase: insights into the relationship between the soluble and the membrane‐bound forms of the enzyme.
- Noradrenergic-Specific Transcription of the Dopamine β-Hydroxylase Gene Requires Synergy of MultipleCis-Acting Elements Including at Least Two Phox2a-Binding Sites
- Effect of cold pressor stimulation on plasma norepinephrine, dopamine-beta-hydroxylase, and renin activity.
- Depression, antidepressants, and plasma DBH.
- Concentrations of monoamine metabolites in the cerebrospinal fluid of twins and unrelated individuals--a genetic study.
- Plasma norepinephrine, epinephrine, and dopamine beta-hydroxylase activity during exercise in man.
- Reduced plasma dopamine-beta-hydroxylase activity in familial dysautonomia.
- Linkage analysis of the human dopamine beta-hydroxylase gene.
- Serum Dopamine-β-Hydroxylase Activity: Sibling-Sibling Correlation
- Functional variants at CYP2A6: new genotyping methods, population genetics, and relevance to studies of tobacco dependence.
- Serum dopamine-beta-hydroxylase activity in patients with Huntington's chorea and Parkinson's disease.
Cited by
- Could the inter-individual variability in cocaine-induced psychotic effects influence the development of cocaine addiction? Towards a new pharmacogenetic approach to addictions.
- Biochemical markers and genetic research of ADHD.
- Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers
- Dopamine-beta-hydroxylase in postural tachycardia syndrome.
- Association study between the -1021C/T polymorphism of the dopamine-beta-hydroxylase gene promoter and personality traits in healthy subjects.
- Dopamine Beta Hydroxylase Genotype Identifies Individuals Less Susceptible to Bias in Computer-Assisted Decision Making
- Genetic Factors Modulating the Response to Stimulant Drugs in Humans
- Recherche de facteurs génétiques intervenant dans la variabilité de la réponse aux opioïdes dans le traitement de la douleur et les traitements de substitution
- The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking
- Polymorphisms in dopamine metabolic enzymes and tobacco consumption in smokers: seeking confirmation of the association in a follow-up study.
- ABO Blood Type and Personality Traits in Healthy Japanese Subjects
- The DBH 21021 C=T polymorphism is not associated with alcoholism but possibly with patients' exposure to life events Short Communication
- Pharmacogenomics in Drug Discovery and Development
- A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease
- Posttraumatic stress disorder with secondary psychotic features: neurobiological findings.
- Effect of imipramine treatment on plasma dopamine beta-hydroxylase activity in chronic mild stress in rats.
- An initial investigation of associations between dopamine-linked genetic variation and smoking motives in African Americans
- Pharmacogenetics of alcohol, nicotine and drug addiction treatments
- Tumour Necrosis Factor Gene Polymorphism and Disease Prevalence
- No association of SIDS with two polymorphisms in genes relevant for the noradrenergic system: COMT and DBH
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