CD4+ T cells initiate pancreatic islet xenograft rejection via an interferon-gamma-dependent recruitment of macrophages and natural killer cells.

Keywords

Islet, Interferon, Cancer research, Transplantation, Immunology

References

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Cited by

• Immunological challenges and therapies in xenotransplantation.Gaetano Pecora — 2014
• Studies of Innate and Adaptive Immunity in Islet TransplantationMaria Hårdstedt — 2014
• Immunadsorption bei der heterotopen und orthotopen Xenotransplantation von Pavianen, Cynomolgus- und Rhesusaffen mit Landrasse- und hDAF-transgenen SchweineherzenVeronika Eder — 2004
• Xenoreactive CD4+ memory T cells resist inhibition by anti‐CD44 mAb and reject islet grafts via a Th2‐dependent pathwayYuanzheng Peng, Jibing Chen, Wei Shao — 2011
• CD4 T-cells Mediate Cardiac Xenograft Rejection via Host MHC class IIRobert J. Plenter, Todd J. Grazia, An N. Doan — 2012
• Chemokine and toll‐like receptor signaling in macrophage mediated islet xenograft rejectionAbhilash P. Chandra, Ouyang Li, Shounan Yi — 2007
• Xenogeneic transplantation of porcine islets: an overviewDebra MacKenzie, Debra A. Hullett, Hans W. Sollinger — 2003
• Prevention of primary non-function of islet xenografts in autoimmune diabetic NOD mice by anti-inflammatory agentsConny Gysemans, Katinka Stoffels, Annapaula Giulietti — 2003
• Transient transmission of porcine endogenous retrovirus to fetal lambs after pig islet tissue xenotransplantationSarah K. Popp, David A. Mann, Peter J. Milburn — 2007
• Role of CD4+ and CD8+ T cells in the rejection of heart or islet xenografts in recipients with xenotolerance in the innate immune compartment.Timothy Devos, Yihe Yan, Constant Segers — 2005
• Pathogenesis and pathology of different types of xenotransplant rejectionEmanuele Cozzi, M Seveso, Ermanno Ancona — 2004
• Transplantation of Xenogeneic Islets: Are We There Yet?Philip J. O’Connell, Peter J. Cowan, Wayne J. Hawthorne — 2013
• Xenotransplantation: immunological hurdles and progress toward toleranceAdam Griesemer, Kazuhiko Yamada, Megan Sykes — 2014
• IFN‐γ but not IL‐4 is important for mouse CD4+ T cell‐mediated macrophage activation following their exposure to pig cells in vitroShounan Yi, Philip J. O’Connell — 2002
• Islet xenotransplantation: progress towards a clinical therapyPhilip J. O’Connell, Andrew M. Lew, Peter J. Cowan — 2006
• Transgenic expression of HLA‐E single chain trimer protects porcine endothelial cells against human natural killer cell‐mediated cytotoxicityBenjamin G. Lilienfeld, Mark D. Crew, Pietro Forte — 2007
• Role of regulatory T cells in xenotransplantationPhilip J. O’Connell, Shounan Yi, Emma M. Carrington — 2010
• The immunological barriers to xenotransplantation.Marta Vadori, Emanuele Cozzi — 2015
• Reversal of diabetes in non‐immunosuppressed rhesus macaques by intraportal porcine islet xenografts precedes acute cellular rejectionNicole Kirchhof, Satoshi Shibata, Martin Wijkstrom — 2004
• Immune mechanisms associated with the rejection of encapsulated neonatal porcine islet xenograftsTsunehiro Kobayashi, George Harb, Ray V. Rajotte — 2006

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