Epigenetic regulation and the variability of gene expression
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Summary
It is proposed that epigenetic regulation has a central role in the variation and evolution of gene expression and the correlation of TATA-box presence and expression variability could be explained in terms of chromatin regulation.
- Type
- article
- Published
- 2008-02-01
- Cited by
- 112
- References
- 30
- OpenAlex
- https://openalex.org/W1974094308
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34207485
Keywords
Biology, Chromatin, Epigenetics, Genetics, Histone
References
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- Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast
- The landscape of genetic complexity across 5,700 gene expression traits in yeast.
- Chromatin structure and evolution in the human genome
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- A genome-wide analysis in Saccharomyces cerevisiae demonstrates the influence of chromatin modifiers on transcription
- Identification and distinct regulation of yeast TATA box-containing genes.
- Interplay of TBP inhibitors in global transcriptional control.
- Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters.
- Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
- Central role of Ifh1p–Fhl1p interaction in the synthesis of yeast ribosomal proteins
- Proteome survey reveals modularity of the yeast cell machinery
- A role for TBP dimerization in preventing unregulated gene expression.
- Genetic reconstruction of a functional transcriptional regulatory network
- Transcriptional regulatory code of a eukaryotic genome
- Global and specific transcriptional repression by the histone H3 amino terminus in yeast
- Identifying regulatory mechanisms using individual variation reveals key role for chromatin modification
- A genetic signature of interspecies variations in gene expression
- Genetic Dissection of Transcriptional Regulation in Budding Yeast
- Genome-wide map of nucleosome acetylation and methylation in yeast.
Cited by
- Reduced Representation Bisulfite Sequencing of Human Neutrophils Reveals Widespread Inter-Individual Epigenetic Variation
- Coordinated histone modifications are associated with gene expression variation within and between species.
- DNA methylation and transcriptional noise
- Yin and Yang of disease genes and death genes between reciprocally scale-free biological networks
- Balancing noise and plasticity in gene expression
- Global expression analysis of human cells and tissues using antibodies
- Evolutionary Systems Biology in Yeast
- Epigenetic Regulation of Dopamine Transporter mRNA Expression in Human Neuroblastoma Cells
- DNA Sequence Preferences of Transcriptional Activators Correlate More Strongly than Repressors with Nucleosomes
- Tandem repeat variation in human and great ape populations and its impact on gene expression divergence
- Variable Glutamine-Rich Repeats Modulate Transcription Factor Activity
- Genetic Architecture of Transcription and Chromatin Regulation
- Nuclear factor κB (NF-κB) suppresses food intake and energy expenditure in mice by directly activating the Pomc promoter
- Intrinsic variability of gene expression encoded in nucleosome positioning sequences
- Over-expression of Arabidopsis AtCHR23 chromatin remodeling ATPase results in increased variability of growth and gene expression
- Cis- and trans-regulatory divergence between progenitor species determines gene-expression novelty in Arabidopsis allopolyploids
- Analysis of DNA methylation of perennial ryegrass under drought using the methylation-sensitive amplification polymorphism (MSAP) technique
- Nucleosome positioning: how is it established, and why does it matter?
- Robustness of transcriptional regulatory program influences gene expression variability
- Chromatin Regulation and Gene Centrality Are Essential for Controlling Fitness Pleiotropy in Yeast
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