A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation.
Explore this paper's citation graph
Summary
It is proposed that during ischemia, neutrophil Fpr2/3 controls platelet/neutrophil aggregates with the rapid generation of circulating LXA4, which in turn modulates downstream vascular inflammatory responses evident during the reperfusion phase.
- Type
- article
- Published
- 2013-07-25
- Cited by
- 99
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W1974048267
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7592610
Keywords
Extravasation, Inflammation, Intravital microscopy, Pharmacology, Formyl peptide receptor
References
- Non-prostaglandin effects of aspirin III and salicylate: inhibition of integrin-dependent human neutrophil aggregation and inflammation in COX 2- and NF kappa B (P105)-knockout mice.
- Cutting Edge: Lipoxins Rapidly Stimulate Nonphlogistic Phagocytosis of Apoptotic Neutrophils by Monocyte-Derived Macrophages1
- Lipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: role of P-selectin.
- Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes.
- The neutrophil in vascular inflammation
- Resolution of inflammation: the beginning programs the end
- Chemical Mediators of Inflammation and Resolution in Post-Operative Abdominal Aortic Aneurysm Patients
- Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog.
- Anti-inflammatory effects of aspirin and sodium salicylate.
- Activation of the annexin 1 counter‐regulatory circuit affords protection in the mouse brain microcirculation
- Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms.
- Annexins: linking Ca2+ signalling to membrane dynamics
- Points of control in inflammation
- Physiological functions of glucocorticoids in stress and their relation to pharmacological actions.
- The resolution of inflammation: the devil in the flask and in the details
- Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions.
- Up-Regulation of Annexin-A1 and Lipoxin A4 in Individuals with Ulcerative Colitis May Promote Mucosal Homeostasis
- Augmentation of Myocardial Production of 15-Epi-Lipoxin-A4 by Pioglitazone and Atorvastatin in the Rat
- Neutrophil depletion attenuates human intestinal reperfusion injury.
- Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing
Cited by
- Treatment with acetylsalicylic acid prevents short to mid-term radiographic progression of nontraumatic osteonecrosis of the femoral head: a pilot study.
- Specialised lipid mediators and their targets.
- Prostanoids and NSAIDs in Cardiovascular Biology and Disease
- Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7
- The role of platelets in the recruitment of leukocytes during vascular disease
- Lipoxins and aspirin-triggered lipoxins in resolution of inflammation.
- Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis
- The role of the FPR2/ALX receptor in atherosclerosis development and plaque stability
- Polyunsaturated Fatty Acid Metabolism Signature in Ischemia Differs from Reperfusion in Mouse Intestine
- Lipoxin A4 Inhibits NF-κB Activation and Cell Cycle Progression in RAW264.7 Cells
- Novel Pro-Resolving Lipid Mediators in Inflammation Are Leads for Resolution Physiology
- Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.
- Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes associated with the ERK1/2 and NF-κB pathways.
- Antiinflammatory effects of aspirin in ACS: relevant to its cardio coronary actions?
- Lipid mediators in the resolution of inflammation.
- Aspirin and P2Y12 Inhibitors in platelet-mediated activation of neutrophils and monocytes
- Modulation of Voltage-Dependent and Inward Rectifier Potassium Channels by 15-Epi-Lipoxin-A4 in Activated Murine Macrophages: Implications in Innate Immunity
- Slowing the progression of age-related hearing loss: Rationale and study design of the ASPIRIN in HEARING, retinal vessels imaging and neurocognition in older generations (ASPREE-HEARING) trial
- Acute Inflammation: A Protective Host Response that May Turn into Harm
- The role of FPR2/ALX in the vascular wall
Related papers
- Late effects of TNF-alpha-induced inflammation on the microcirculation of cremaster muscle flaps under intravital microscopy.
- A novel approach to the study of human microcirculation: reactivity to locally applied angiotensin II in the conjunctival microvascular bed
- The subepicardial microcirculation in heterotopically transplanted mouse hearts: an intravital multifluorescence microscopy study.
- Isolated cremaster flap: A modified model in intravital microscopy
- Intravital microscopic evaluation of cremasteric microcirculation in experimental testicular torsion.
- Intravital Microscopy of the Mouse Brain Microcirculation using a Closed Cranial Window
- What Formyl Peptide Receptors, if Any, Are Triggered by Compound 43 and Lipoxin A4?