Structure, evolution, and biology of the MUC4 mucin
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Summary
The heavily glycosylated tandem repeat domain provides the structural rigidity to the extended extracellular region of MUC4, which serves as a barrier for some cell‐cell and cell‐extracellular matrix interactions and as a potential reservoir for certain growth factors.
- Type
- review
- Published
- 2008-04-01
- Cited by
- 249
- References
- 128
- Access
- Open access
- OpenAlex
- https://openalex.org/W1973793754
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10382484
Keywords
Mucin, Biology, Cell biology, Signal transduction, Transcription factor
References
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- Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7).
- The EGF domain: requirements for binding to receptors of the ErbB family.
- Alternative splicing generates a family of putative secreted and membrane-associated MUC4 mucins.
- IL-4 induced MUC4 enhancement in respiratory epithelial cells in vitro is mediated through JAK-3 selective signaling
- Progression model for pancreatic cancer.
- MUC1 and the Immunobiology of Cancer
- Mucins of the human endocervix.
- Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin.
- Mucins in the gastrointestinal tract in health and disease.
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- Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance.
- Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway.
- Genomic organization of MUC4 mucin gene. Towards the characterization of splice variants.
- Antiviral Activity of Purified Human Breast Milk Mucin
- MUC1 is a novel regulator of ErbB1 receptor trafficking
- MUC4 mucin expression in human pancreatic tumours is affected by organ environment: the possible role of TGFβ2
- Multiple roles of mucins in pancreatic cancer, a lethal and challenging malignancy
- Aberrant expression of transmembrane mucins, MUC1 and MUC4, in human prostate carcinomas
Cited by
- Histological and immunohistochemical analyses of splenic epidermoid cysts.
- The evolving role of MUC16 (CA125) in the transformation of ovarian cells and the progression of neoplasia.
- Salives et milieu buccal
- Human Milk Composition: Nutrients and Bioactive Factors
- Interfacial properties of mucins
- Effect of Stress on Mucin Expression in the Gastrointestinal Tract of Mice.
- Régulation de l’expression de la mucine MUC4 par les miARN et identification de nouveaux miARN dans le cancer du pancréas
- The Role of nAChR and Calcium Signaling in Pancreatic Cancer Initiation and Progression
- Molecular pathology of early pancreatic cancer
- Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer
- Comparative molecular approaches to identify host determinants mediating adhesion of E. coli F4 strains in pigs
- Development of human minor salivary glands: expression of mucins according to stage of morphogenesis
- Co‐expression of HER3 and MUC1 is associated with a favourable prognosis in patients with bladder cancer
- Pancreatic Cancer - Early Detection, Prognostic Factors, and Treatment
- Anti-infective control in human bronchiolar epithelial cells by mucin phenotypic changes following uptake of N-acetyl-L-cysteine
- Altered Mucins (MUC) Trafficking in Benign and Malignant Conditions
- An update on the application of newly described immunohistochemical markers in soft tissue pathology.
- Tenectin is a novel αPS2βPS integrin ligand required for wing morphogenesis and male genital looping in Drosophila
- Role of Mucins in the Skin during Benign and Malignant Conditions
- MUC4 Overexpression Augments Cell Migration and Metastasis through EGFR Family Proteins in Triple Negative Breast Cancer Cells
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