Mitochondrial Respiratory Chain Deficiency inCaenorhabditis elegans Results in Developmental Arrest and Increased Life Span*
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Summary
The common phenotype induced by the mutations and drugs suggests that the L3-to-L4 transition may involve an energy-sensing developmental checkpoint, and it is predicted that L3 arrest will be characteristic of mutations in these genes.
- Type
- article
- Published
- 2001-08-24
- Cited by
- 155
- References
- 49
- Access
- Open access
- OpenAlex
- https://openalex.org/W1973722927
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26848491
Keywords
Biology, Caenorhabditis elegans, Mitochondrial biogenesis, Respiratory chain, ATP synthase
References
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- Assembly of mitochondrial ATP synthase in cultured human cells: implications for mitochondrial diseases.
- Human mitochondrial complex I in health and disease.
- Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.
- Clinical differences in patients with mitochondriocytopathies due to nuclear versus mitochondrial DNA mutations
- Mitochondrial Respiratory Chain Diseases and Mutations in Nuclear DNA: A Promising Start?
Cited by
- Insulin secretion and ASNA-1-dependent function of the endoplasmic reticulum in C. elegans
- Role of Mitochondrial Dynamics and Autophagy in Removal of Helix-Distorting Mitochondrial DNA Damage
- Analysis of aging in Caenorhabditis elegans.
- Microarray analysis of oxidative phosphorylation disorders
- Axons degenerate in the absence of mitochondria in C. elegans
- The tobacco‐specific nitrosamine 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) induces mitochondrial and nuclear DNA damage in Caenorhabditis elegans
- Caenorhabditis elegans expressing the Saccharomyces cerevisiae NADH alternative dehydrogenase Ndi1p, as a tool to identify new genes involved in complex I related diseases
- Functional analysis of the unconventional prefoldin URI-1 in Caenorhabditis elegans
- Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans
- Opposing function of mitochondrial prohibitin in aging
- Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans
- The evolutionary duplication and probable demise of an endodermal GATA factor in Caenorhabditis elegans.
- Bonsaï, a ribosomal protein S15 homolog, involved in gut mitochondrial activity and systemic growth.
- Mitochondrial DNA‐Deficient Models and Aging
- Mitochondrial DNA level, but not active replicase, is essential for Caenorhabditis elegans development
- A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans
- Is life span extension in single gene long-lived Caenorhabditis elegans mutants due to hypometabolism?
- Molecular characterisation of the recovery process in the entomopathogenic nematode Heterorhabditis bacteriophora.
- Knockdown of Mitochondrial Heat Shock Protein 70 Promotes Progeria-like Phenotypes in Caenorhabditis elegans*
- URI-1 is required for DNA stability in C. elegans
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