The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs.

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Summary

Examination of the hb 3'UTR reveals potential binding sites for known fly miRNAs and finds that hbl-1/lin-57 is regulated by let-7, at least in the nervous system, which suggests evolutionary conservation of hunchback genes may include temporal control of cell fate specification and microRNA-mediated regulation.

Type
article
Published
2003-05-01
Cited by
390
References
57
Access
Open access

Keywords

Biology, Caenorhabditis elegans, microRNA, Gene, Genetics

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