The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs.
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Summary
Examination of the hb 3'UTR reveals potential binding sites for known fly miRNAs and finds that hbl-1/lin-57 is regulated by let-7, at least in the nervous system, which suggests evolutionary conservation of hunchback genes may include temporal control of cell fate specification and microRNA-mediated regulation.
- Type
- article
- Published
- 2003-05-01
- Cited by
- 390
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W1973699456
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5866443
Keywords
Biology, Caenorhabditis elegans, microRNA, Gene, Genetics
References
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Cited by
- A Biochemical Dissection of the RNA Interference Pathway in Drosophila melanogaster : A Dissertation
- Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation
- Tissue and Process Specific microRNA–mRNA Co-Expression in Mammalian Development and Malignancy
- MicroRNAs in breast cancer
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- MIR-237 is Likely a Developmental Timing Gene that Regulates the L2-to-L3 Transition in C. Elegans
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- Heterochronic control of AFF-1-mediated cell-to-cell fusion in C. elegans.
- Cooperativity in Mammalian RNA Silencing: A Dissertation
- Régulation post-transcriptionnelle du gène unc-54 de Caenorhabditis elegans identifiée in vivo par un système de double rapporteurs fluorescents
- The miR-1000-p53 pathway regulates apoptosis and virus infection in shrimp.
- RBMMMDA: predicting multiple types of disease-microRNA associations
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