A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation.
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Summary
The G-CSFR is generating unique signals that are required for certain specialized hematopoietic cell functions but are not required for granulocytic differentiation or lineage commitment.
- Type
- article
- Published
- 1999-08-01
- Cited by
- 100
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W1973681951
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24198686
Keywords
Biology, Haematopoiesis, Cell biology, Receptor, Bone marrow
References
- Optimization of flow-cytometric discrimination between reticulocytes and erythrocytes.
- The granulocyte colony-stimulating factor receptor is required for the mobilization of murine hematopoietic progenitors into peripheral blood by cyclophosphamide or interleukin-8 but not flt-3 ligand.
- Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl.
- Distinct regions of the granulocyte colony-stimulating factor receptor are required for tyrosine phosphorylation of the signaling molecules JAK2, Stat3, and p42, p44MAPK.
- Transplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor.
- Cytokine receptor expression on hematopoietic stem and progenitor cells.
- Ectopic expression of the erythropoietin receptor in a murine interleukin-6-dependent plasmacytoma cell line (TEPC-2027) confers proliferative responsiveness to erythropoietin.
- Granules of the human neutrophilic polymorphonuclear leukocyte.
- Increased tolerance to endotoxin by granulocyte-macrophage colony-stimulating factor-deficient mice.
- Distinct signal transduction through the tyrosine‐containing domains of the granulocyte colony‐stimulating factor receptor.
- Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo.
- Chemotactic potency of recombinant human neutrophil attractant/activation protein-1 (interleukin-8) for polymorphonuclear leukocytes of different species.
- Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors.
- Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions
- Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology.
- Expression of granulocyte colony‐stimulating factor receptor increases with differentiation in myeloid cells by a newly‐devised quantitative flow‐cytometric assay
- Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice.
- Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis.
- Mutant protein of recombinant human granulocyte colony-stimulating factor for receptor binding assay.
- Involvement of STAT3 in the Granulocyte Colony-stimulating Factor-induced Differentiation of Myeloid Cells*
Cited by
- Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors
- Hsp70 est un nouveau régulateur majeur de l'érythropoïèse empêchant le clivage du facteur de transcription GATA-1 par la caspase-3 au cours de la différenciation.
- The Hematopoietic Compartment Regulates Osteoblast Differentiation And Apoptosis During Cytokine Treatment
- Regulation of neutrophil homeostasis by chemokines signaling through the CXCR2 and CXCR4 receptors
- Promoting Thymopoiesis with Age: Potential Role of the Transcription Factor Foxn1
- Lineage commitment and developmental plasticity in early lymphoid progenitor subsets.
- Granulocyte colony-stimulating factor receptor: structure and function.
- Human bone marrow granulocyte‐ macrophageal colonies (GM‐Cs) in vitro: Myeloid cells in health and in cases of myeloid leukemia
- G‐CSF preferentially supports the generation of gut‐homing Gr‐1high macrophages in M‐CSF‐treated bone marrow cells
- Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis
- Receptor specificity in the self-renewal and differentiation of primary multipotential hemopoietic cells.
- STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation.
- Developmental plasticity of lymphoid progenitors.
- Thrombopoietin induces histidine decarboxylase gene expression in c-mpl transfected UT7 cells.
- New light on the biology and developmental potential of haematopoietic stem cells and progenitor cells
- Protective and pathogenic functions of macrophage subsets
- Instruction of hematopoietic lineage choice by cytokine signaling.
- Neutrophil homeostasis
- Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment.
- Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cells.
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