Tamoxifen: an emerging preventive.
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Summary
Comparing tamoxifen to placebo (for 5 years) has shown that tamoxIfen significantly reduced the risk of breast cancer recurrence, in those with a history of the disease and reduced or delayed breast cancer progression, from an noninvasive to invasive breast cancer.
- Type
- review
- Published
- 2004-09-01
- Cited by
- 11
- References
- 126
- Access
- Open access
- OpenAlex
- https://openalex.org/W1973526478
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6779723
Keywords
Tamoxifen, Breast cancer, Medicine, Oncology, Estrogen receptor
References
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- The aromatase inactivator 4-hydroxyandrostenedione (4-OH-A) inhibits tamoxifen metabolism by rat hepatic cytochrome P-450 3A: potential for drug-drug interaction of tamoxifen and 4-OH-A in combined anti-breast cancer therapy.
- Tamoxifen for early breast cancer: an overview of the randomised trials
- Stable transfection of protein kinase C alpha cDNA in hormone-dependent breast cancer cell lines
- Tamoxifen inhibits secretion of vascular endothelial growth factor in breast cancer in vivo.
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- The Breast Cancer Continuum: insights from the tamoxifen trials impact future drug development strategies.
- CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver.
- Changes in estrogen receptor, progesterone receptor, and pS2 expression in tamoxifen-resistant human breast cancer.
- Analysis of phase I and phase II metabolites of tamoxifen in breast cancer patients.
- The Royal Marsden Hospital (RMH) Trial
- ErbB (HER) receptors can abrogate antiestrogen action in human breast cancer by multiple signaling mechanisms.
- Activity of exemestane in metastatic breast cancer after failure of nonsteroidal aromatase inhibitors: a phase II trial.
- Novel antitumor effect of estradiol in athymic mice injected with a T47D breast cancer cell line overexpressing protein kinase Calpha.
Cited by
- Bioanalysis and clinical pharmacology of tamoxifen in breast cancer
- Development and validation of a quantitative assay for the analysis of tamoxifen with its four main metabolites and the flavonoids daidzein, genistein and glycitein in human serum using liquid chromatography coupled with tandem mass spectrometry.
- Cancer T47D Cells by Immunocytochemistry
- Development and validation of a quantitative assay for the determination of tamoxifen and its five main phase I metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry.
- Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques.
- Bioanalytical methods for determination of tamoxifen and its phase I metabolites: a review.
- Selective estrogen receptor modulators
- The estrogen receptor modulator tamoxifen enhances spontaneous glycinergic synaptic inhibition of hypoglossal motoneurons.
- Tamoxifen and mifepriston modulate nicotine induced conditioned place preference in female rats.
- Unexpected Z-stereoselectivity in the Ramberg-Bäcklund reaction of diarylsulfones leading to cis-stilbenes: the effect of aryl substituents and application in the synthesis of the integrastatin nucleus.
- In vitro phase I metabolism of selective estrogen receptor modulators in horse using ultra-high performance liquid chromatography-high resolution mass spectrometry.
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