Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors.
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Summary
Given the ubiquitous expression of the GABA(A) receptor throughout the mammalian central nervous system (CNS), physiological, pathophysiological, or drug-induced pertubations of neurosteroid levels may be expected to produce widespread changes in brain excitability, however, the neurosteroids/GABA(A), receptor interaction is brain region and indeed neuron specific.
- Type
- review
- Published
- 2007-10-01
- Cited by
- 213
- References
- 140
- Access
- Open access
- OpenAlex
- https://openalex.org/W1973115552
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:35730222
Keywords
Neuroactive steroid, GABAA receptor, GABAA-rho receptor, Neuroscience, Anxiolytic
References
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- Neurosteroid Prolongs GABAA Channel Deactivation by Altering Kinetics of Desensitized States
- GABAA receptor α4 subunit suppression prevents withdrawal properties of an endogenous steroid
- Differential Expression of α1, α2, α3, and α5 GABAA Receptor Subunits in Seizure-Prone and Seizure-Resistant Rat Models of Temporal Lobe Epilepsy
- Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors
- Supersensitivity to allosteric GABAA receptor modulators and alcohol in mice lacking PKCε
- Anabolic steroids induce region- and subunit-specific rapid modulation of GABA(A) receptor-mediated currents in the rat forebrain.
- Slow Kinetics of Miniature IPSCs during Early Postnatal Development in Granule Cells of the Dentate Gyrus
- Neurosteroids Shift Partial Agonist Activation of GABAA Receptor Channels from Low- to High-Efficacy Gating Patterns
- GABAA Receptor ε and θ Subunits Display Unusual Structural Variation between Species and Are Enriched in the Rat Locus Ceruleus
Cited by
- Insights into the structure and pharmacology of GABA(A) receptors.
- GABA beyond the synapse: defining the subtype‐specific pharmacodynamics of non‐synaptic GABAA receptors
- Regulation of GABAARs by Phosphorylation
- Side effects of anabolic androgenic steroids: pathological findings and structure-activity relationships.
- Regulation of hippocampal synaptic plasticity by estrogen and progesterone.
- ERK/MAPK Pathway Regulation of GABA-A Receptor Function.
- Comparative aspects of neurosteroidogenesis: From fish to mammals.
- Implication du sexe, des hormones gonadiques et de leurs métabolites dans la réponse nociceptive et la perception de la douleur
- Functional properties of 4-PIOL at synaptic and extrasynaptic GABA-A receptors
- Mechanisms of Seizure during Pregnancy and Preeclampsia
- Impact des glucocorticoïdes circulants sur la maturation et le fonctionnement de l'inhibition spinale GABAergique
- Investigations Of The Mechanism And Modulation Of Gaba(A) Receptors And Their Potentiation By Dihydropyrimidinones
- The Contribution of Normal Pregnancy to Eclampsia
- Differential interactions engendered by benzodiazepine and neuroactive steroid combinations on schedule-controlled responding in rats
- The effects of lavandula angustifolia on animal and human laboratory models of anxiety
- DNA methylation of the GC box in the promoter region mediates isolation rearing-induced suppression of srd5a1 transcription in the prefrontal cortex.
- The Cerebellar GABAa receptor contribution to alcohol intake and intoxication
- GABAA receptor modulation by neurosteroids in models of temporal lobe epilepsies
- Alteration of Ethanol Drinking in Mice via Modulation of the GABAA Receptor with Ganaxolone, Finasteride, and Gaboxadol
- Rebalancing the commissural system: Mechanisms of vestibular compensation
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