Low penetrance susceptibility to glioma is caused by the TP53 variant rs78378222
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Summary
The data provided strong validation of rs78378222 as a risk factor for glioma but do not support the tenet that the polymorphism being a clinically useful prognostic marker.
- Type
- article
- Published
- 2013-04-09
- Cited by
- 58
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W1972933475
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8837065
Keywords
Glioma, Genotyping, Biology, SNP, Single-nucleotide polymorphism
References
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Cited by
- Epidemiology of gliomas.
- Genotype-phenotype studies in brain tumors
- Polymorphisms in G-quadruplex regions of the TP53 tumour suppressor gene : Impact on cancer susceptibility and expression of p53 N-terminal isoforms
- Absence of the TP53 poly-A signal sequence variant rs78378222 in oral, cervical and breast cancers in South India.
- Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations
- Allergic conditions reduce the risk of glioma: a meta-analysis based on 128,936 subjects
- Impaired Pre-mRNA Processing and Altered Architecture of 3′ Untranslated Regions Contribute to the Development of Human Disorders
- mRNA 3′end processing: A tale of the tail reaches the clinic
- Genetics in glioma- lessons learned from genome wide association studies
- Further Confirmation of Germline Glioma Risk Variant rs78378222 in TP53 and Its Implication in Tumor Tissues via Integrative Analysis of TCGA Data
- Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case–Control Study
- The epidemiology of glioma in adults: a "state of the science" review.
- The dichotomy of p53 regulation by noncoding RNAs.
- Rare germline variant (rs78378222) in the TP53 3' UTR: Evidence for a new mechanism of cancer predisposition in Li-Fraumeni syndrome.
- Pre-diagnostic serum levels of EGFR and ErbB2 and genetic glioma risk variants: a nested case-control study
- Understanding inherited genetic risk of adult glioma - a review.
- A novel TP53 variant (rs78378222 A > C) in the polyadenylation signal is associated with increased cancer susceptibility: evidence from a meta-analysis
- Quantifying the heritability of glioma using genome-wide complex trait analysis
- Prevalence of low-penetrant germline TP53 D49H mutation in Japanese cancer patients.
- Relation between Established Glioma Risk Variants and DNA Methylation in the Tumor
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