Free and total lipid myo-inositol concentrations decrease with age in human brain.
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Summary
An active transport system maintains myo-inositol in the brain at a much higher concentration than in the blood, and there was a similar fall with age in the total inositol lipid concentration.
- Type
- article
- Published
- 1983-08-29
- Cited by
- 43
- References
- 9
- OpenAlex
- https://openalex.org/W1972357335
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37727481
Keywords
Inositol, Human brain, Chemistry, Endocrinology, Internal medicine
References
- Transport of myo-inositol into endoneurial preparations of sciatic nerve from normal and streptozotocin-diabetic rats.
- Is phosphatidylinositol really out of the calcium gate?
- Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes.
- Significance of tissue myo-inositol concentrations in metabolic regulation in nerve.
- Sodium- and energy-dependent uptake of myo-inositol by rabbit peripheral nerve. Competitive inhibition by glucose and lack of an insulin effect.
- Inositol phospholipids and cell surface receptor function.
- Is phosphatidylinositol now out of the calcium gate?
- Free and lipid myo-inositol in tissues from rats with acute and less severe streptozotocin-induced diabetes.
- Myo-inositol homeostasis in foetal rabbit lung.
Cited by
- Nicergoline in Dementia
- Phosphoinositides and synaptic transmission.
- Characterization and identification of novel regulators of the synthesis of phospholipids
- Nicergoline : A Drug for Dementia and Vertigo
- Localized 13C NMR spectroscopy of myo‐inositol in the human brain in vivo
- Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance
- High brain myo-inositol levels in the predementia phase of Alzheimer's disease in adults with Down's syndrome: a 1H MRS study.
- Aging and Calcitriol Regulation of IP3 Production in Rat Skeletal Muscle and Intestine
- Insulin modifies aging-related inhibition of 1-stearoyl, 2-arachidonoylglycerol phosphorylation in rat synaptic terminals.
- Age-associated decrease in inositol 1,4,5-trisphosphate and diacylglycerol generation by 1,25(OH)2-vitamin D3 in rat intestine.
- An in vitro 1H nuclear magnetic resonance study of the temporoparietal cortex of Alzheimer brains
- Neurite‐Promoting Activities of Phosphatidylinositol and Other Lipids on Fetal Rat Septal Neurons in Culture
- Modulation of phosphoinositide turnover by chronic nicergoline in rat brain.
- Inositol phosphates and intracellular calcium after bradykinin stimulation in fibroblasts from young, normal aged and Alzheimer donors.
- Quantitative analysis of polyols in human plasma and cerebrospinal fluid.
- Rapid modulation of Ca2+ uptake in human jejunal enterocytes.
- Aging-related regulation of myo-inositol 1,4,5-trisphosphate signal transduction pathway in the rat striatum.
- Inositol synthesis regulates activation of GSK-3α in neuronal cells
- TonEBP and SMIT expression in human placenta
- Quantitation of normal metabolite concentrations in six brain regions by in-vivo 1H-MR spectroscopy
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